A critical view on transgenerational epigenetic inheritance in humans.
TLDR
The phenomenon of transgenerational epigenetic inheritance is discussed and the difficulty of providing conclusive proof for it in experimental and observational studies is discussed.Abstract:
Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the study of transgenerational epigenetic inheritance is confounded by genetic, ecological and cultural inheritance. In this comment, I discuss the phenomenon of transgenerational epigenetic inheritance and the difficulty of providing conclusive proof for it in experimental and observational studies.read more
Citations
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The future of rodent models in depression research.
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Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma.
TL;DR: A platform on which the field of ACE-induced phenotypes in mental health may build is provided, with suggestions for advances using new technologies and novel research directions.
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Metabolic regulation of kisspeptin - the link between energy balance and reproduction.
TL;DR: The novel role of kisspeptin neurons as active players within the neuronal circuits that govern energy balance is discussed, offering evidence of a bidirectional role of these neurons as a nexus between metabolism and reproduction.
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Phthalate Exposure and Long-Term Epigenomic Consequences: A Review
TL;DR: This review focusses on studies conducted in the field of toxicogenomics of phthalates and discusses possible transgenerational and multigenerational effects caused by phthalate exposure during any point of the life-cycle.
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Genetic impacts on DNA methylation: research findings and future perspectives.
Sergio Villicaña,Jordana T. Bell +1 more
TL;DR: A review of recent milestones in characterizing the human genetic basis of DNA methylation variation over the last decade, including heritability findings and genome-wide identification of meQTLs, can be found in this paper.
References
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Journal ArticleDOI
Transgenerational Epigenetic Inheritance: myths and mechanisms
TL;DR: Although the inheritance of epigenetic characters can certainly occur-particularly in plants-how much is due to the environment and the extent to which it happens in humans remain unclear.
Journal ArticleDOI
Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice
Katharina Gapp,Ali Jawaid,Peter Sarkies,Johannes Bohacek,Pawel Pelczar,Julien Prados,Laurent Farinelli,Eric A. Miska,Isabelle M. Mansuy +8 more
TL;DR: Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment and injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
Journal ArticleDOI
Editing DNA Methylation in the Mammalian Genome
X. Shawn Liu,Hao Wu,Xiong Ji,Yonatan Stelzer,Xuebing Wu,Szymon Czauderna,Szymon Czauderna,Jian Shu,Daniel B. Dadon,Richard A. Young,Rudolf Jaenisch +10 more
TL;DR: In this paper, a fusion of Tet1 or Dnmt3a with a catalytically inactive Cas9 (dCas9) enables targeted DNA methylation editing, which is a critical epigenetic mechanism orchestrating gene expression networks in many biological processes.
Journal ArticleDOI
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1
Marjolijn J L Ligtenberg,Roland P. Kuiper,Tsun Leung Chan,Tsun Leung Chan,Monique Goossens,Konnie M. Hebeda,Marsha Voorendt,Tracy Y H Lee,Danielle Bodmer,Eveline Hoenselaar,Sandra J B Hendriks-Cornelissen,Wai Yin Tsui,Chi Kwan Kong,Han G. Brunner,Ad Geurts van Kessel,Siu Tsan Yuen,Siu Tsan Yuen,J. Han van Krieken,Suet Yi Leung,Suet Yi Leung,Nicoline Hoogerbrugge +20 more
TL;DR: Patients from Dutch and Chinese families with MSH2-deficient tumors carrying heterozygous germline deletions of the last exons of TACSTD1, a gene directly upstream of MSH1 encoding Ep-CAM, are described, revealing a correlation between activity of the mutated TAC STD1 allele and epigenetic inactivation of the corresponding MSH 2 allele.
Editing DNA Methylation in the Mammalian Genome
X. Shawn Liu,Hao Wu,Xiong Ji,Yonatan Stelzer,Xuebing Wu,Szymon Czauderna,Szymon Czauderna,Jian Shu,Daniel B. Dadon,Richard A. Young,Rudolf Jaenisch +10 more
TL;DR: Fusion of Tet1 or Dnmt3a with a catalytically inactive Cas9 enables targeted DNA methylation editing and these tools can editDNA methylation in mice, demonstrating their wide utility for functional studies of epigenetic regulation.
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