Journal ArticleDOI
A factor in spent media from Sertoli-cell-enriched cultures that stimulates steroidogenesis in Leydig cells.
Guido Verhoeven,Jean Cailleau +1 more
TLDR
The observation that the production of this factor by Sertoli cell cultures is stimulated by FSH and dbcAMP suggests that, in the testis, it may play a role in the paracrine control of Leydig cell function.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 1985-04-01. It has received 125 citations till now. The article focuses on the topics: Leydig cell & Sertoli cell.read more
Citations
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Journal ArticleDOI
Cell-Cell Interactions in the Testis
TL;DR: In conclusion, the information available indicates that the interactions between different cell types in the testis play an important role in the control and maintenance of testicular functions.
Journal ArticleDOI
Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis
TL;DR: Test data indicate that the inhibin-related gene products synthesized by Sertoli and granulosa cells may form heterodimer or homodimers to serve as intragonadal paracrine signals in the modulation of LH-stimulated androgen biosynthesis and allow cross-communication between the two feedback loops.
Journal ArticleDOI
The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis.
TL;DR: PBR are implicated in the acute stimulation of Leydig cell steroidogenesis possibly by mediating the entry, distribution, and/or availability of cholesterol within mitochondria.
Journal ArticleDOI
The role of thyroid hormone in testicular development and function.
TL;DR: The current review aims at presenting an updated picture of the recent advances made regarding the role of thyroid hormones in male gonadal function.
Book ChapterDOI
Protein secretions of Sertoli cells
TL;DR: The historical description of Sertoli cells as "nurse cells" thus appears to have been accurate and the nurse-cell function is most clearly demonstrated by the proposed mechanism by which germinal cells obtain ferric ions.
References
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Journal ArticleDOI
Gonadotropin binding and stimulation of cyclic adenosine 3': 5' monophosphate and testosterone production in isolated Leydig cells
TL;DR: Gonadotropin binding and stimulation of cyclic adenosine 3':5'-monophosphate (cyclic AMP) formation and testosterone synthesis were studied in collagenase-dispersed interstitial cells from the adult rat testis Binding data were consistent with the presence of a single order of receptors, with no interaction between binding sites as mentioned in this paper.
Journal ArticleDOI
Sertoli–Leydig cell communication via an LHRH-like factor
TL;DR: It is demonstrated that seminiferous tubules from both the rat and the stumptailed macaque contain a factor which has LHRH-like receptor-binding and biological activity in vitro, but which is immunologically distinct from native LHRh.
Journal ArticleDOI
Is there a local feedback from the seminiferous tubules affecting activity of the Leydig cells
Agustin Aoki,Don W. Fawcett +1 more
TL;DR: Silastic tubing containing cyproterone acetate or braided silk sutures impregnated with WIN18446 or ORF-1616 were inserted under the tunica albuginea of the testes and electron micrographs showed hypertrophy of the smooth endoplasmic reticulum and other evidence of Leydig cell stimulation.
Journal ArticleDOI
Rat sertoli cells: a rapid method for obtaining viable cells.
Michael J. Welsh,John P. Wiebe +1 more
TL;DR: Maintenance of the Sertoli-enriched fraction in modified Eagle's minimal essential medium temporarily at 41 C allows preparations of SERToli cell monolayer cultures consisting of 95%-98% Sertolic cells within 3 days.
Journal ArticleDOI
Evaluation of Leydig Cell Function and Gonadotropin Binding in Unilateral and Bilateral Cryptorchidism: Evidence for Local Control of Leydig Cell Function by the seminiferous Tubule
TL;DR: In unilaterally cryptorchid rats, the Leydig cell hypertrophy and loss of LH receptors is confined to the abdominal testis and there is no significant change in these parameters in the scrotal testis, indicating that local factors within the Cryptorchid testis must result in the changes in LeydIG cell function.
Related Papers (5)
Influence of rat seminiferous tubules on Leydig cell testosterone production in vitro.
Is there a local feedback from the seminiferous tubules affecting activity of the Leydig cells
Agustin Aoki,Don W. Fawcett +1 more