Journal ArticleDOI
A Frequency-Shift Method to Measure Shear-Wave Attenuation in Soft Tissues
TLDR
The frequency-shift method, used in ultrasound imaging and seismology, was adapted for shear-wave attenuation measurement in elastography, and provides tissue attenuation, which is relevant diagnostic information to model viscosity, in addition to sheer-wave velocity used to assess elasticity.Abstract:
In vivo quantification of shear-wave attenuation in soft tissues may help to better understand human tissue rheology and lead to new diagnostic strategies. Attenuation is difficult to measure in acoustic radiation force elastography because the shear-wave amplitude decreases due to a combination of diffraction and viscous attenuation. Diffraction correction requires assuming a cylindrical wavefront and an isotropic propagation medium, which may not be the case in some applications. In this paper, the frequency-shift method, used in ultrasound imaging and seismology, was adapted for shear-wave attenuation measurement in elastography. This method is not sensitive to diffraction effects. For a linear frequency dependence of the attenuation, a closed-form relation was obtained between the decrease in the peak frequency of the gamma-distributed wave amplitude spectrum and the attenuation coefficient of the propagation medium. The proposed method was tested against a plane-wave reference method in homogeneous agar–gelatin phantoms with 0%, 10%, and 20% oil concentrations, and hence different attenuations of 0.117, 0.202, and 0.292 $\text {Np}\cdot \text {m}^{-1}$ /Hz, respectively. Applicability to biological tissues was demonstrated with two ex vivo porcine liver samples (0.79 and 1.35 $\text {Np} \,\cdot \, \text {m}^{-1}$ /Hz) and an in vivo human muscle, measured along (0.43 $\text {Np}\,\cdot \, \text {m}^{-1}$ /Hz) and across (1.77 $\text {Np}\cdot \text {m}^{-1}$ /Hz) the tissue fibers. In all cases, the data supported the assumptions of a gamma-distributed spectrum for the source and linear frequency attenuation for the tissue. This method provides tissue attenuation, which is relevant diagnostic information to model viscosity, in addition to shear-wave velocity used to assess elasticity. Data processing is simple and could be performed automatically in real time for clinical applications.read more
Citations
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Journal ArticleDOI
Ultrafast imaging of cell elasticity with optical microelastography.
Pol Grasland-Mongrain,Ali Zorgani,Shoma Nakagawa,Simon Bernard,Lia Mara Gomes Paim,Greg FitzHarris,Stefan Catheline,Guy Cloutier +7 more
TL;DR: This technique, unlike other methods, can provide an elasticity image in less than a millisecond, thus opening the possibility of studying dynamic cellular processes and elucidating new mechanocellular properties, and represents a tractable option for interrogating biomechanical properties of diverse cell types.
Journal ArticleDOI
Viscoelastic Response Ultrasound Derived Relative Elasticity and Relative Viscosity Reflect True Elasticity and Viscosity: In Silico and Experimental Demonstration
TL;DR: The hypothesis that RE and RV linearly correlate to true elasticity and viscosity in tissue is tested and results suggest thatRE and RV are relevant for qualitatively assessing the elastic and viscous properties of tissue.
Journal ArticleDOI
Attenuation of Shear Waves in Normal and Steatotic Livers.
Ashwani K. Sharma,Joseph Reis,Daniel C. Oppenheimer,Deborah J. Rubens,Juvenal Ormachea,Zaegyoo Hah,Kevin J. Parker +6 more
TL;DR: The hypothesis that Steatosis adds a viscous (lossy) component to the liver, which increases shear wave attenuation is supported and the possible utility of the measurements for non-invasive and quantitative assessment of steatosis is indicated.
Journal ArticleDOI
Reconstruction of Viscosity Maps in Ultrasound Shear Wave Elastography
Manish Bhatt,Marine A. C. Moussu,Boris Chayer,François Destrempes,Marc Gesnik,Louise Allard,An Tang,Guy Cloutier +7 more
TL;DR: A frequency-shift method-based framework is presented for the reconstruction of viscosity by analyzing the spectral properties of acoustic radiation force-induced SWs to investigate the feasibility of viscoelastic reconstruction maps in homogeneous as well as heterogeneous samples.
Journal ArticleDOI
Comprehensive Viscoelastic Characterization of Tissues and the Inter-relationship of Shear Wave (Group and Phase) Velocity, Attenuation and Dispersion.
Juvenal Ormachea,Kevin J. Parker +1 more
TL;DR: It was found that shear wave dispersion and attenuation are experimentally linked, consistent with simple predictions based on the rheology of tissues, and can be used individually or jointly to assess tissue viscosity.
References
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Journal ArticleDOI
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