Journal ArticleDOI
A gene homologous to topoisomerase II in African swine fever virus.
R. Garcia-Beato,José M.P. Freije,Carlos López-Otín,Rafael Blasco,Eladio Viñuela,Margarita Salas +5 more
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TLDR
The tree indicates that the ASF virus topoisomerase II gene was present in the virus genome before protozoa, yeasts, and metazoa diverged, and a phylogenetic tree was established.About:
This article is published in Virology.The article was published on 1992-06-01. It has received 41 citations till now. The article focuses on the topics: African swine fever virus & Gene.read more
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DNA topoisomerases: structure, function, and mechanism.
TL;DR: Surprisingly, despite little or no sequence homology, both type IA and type IIA topoisomerases from prokaryotes and the typeIIA enzymes from eukaryotes share structural folds that appear to reflect functional motifs within critical regions of the enzymes.
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African swine fever virus replication and genomics
TL;DR: African swine fever virus (ASFV) is a large icosahedral DNA virus which replicates predominantly in the cytoplasm of infected cells and a similar mechanism of replication to Poxviruses has been proposed for ASFV.
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Giant viruses infecting algae.
TL;DR: DNA sequence analysis of the PBCV-1 genome leads to the prediction that this phycodnavirus has 376 protein-encoding genes and 10 transfer RNA genes, and the predicted gene products of approximately 40% of these genes resemble proteins of known function.
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Viral Eukaryogenesis: Was the Ancestor of the Nucleus a Complex DNA Virus?
TL;DR: It is proposed that several characteristic features of the eukaryotic nucleus derive from its viral ancestry, including mRNA capping, linear chromosomes, and separation of transcription from translation.
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Novel HeLa topoisomerase II is the IIβ isoform : complete coding sequence and homology with other type II topoisomerases
TL;DR: Comparison of the protein sequence for human topo II beta with other type II topoisomerases revealed several conserved motifs and has allowed identification of the likely ATPase- and DNA breakage-reunion domains.
References
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Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.
TL;DR: By analyzing the effects of single base substitutions around the ATG initiator codon in a cloned preproinsulin gene, ACCATGG is identified as the optimal sequence for initiation by eukaryotic ribosomes.
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Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing
TL;DR: An approach to DNA sequencing using chain-terminating inhibitors (Sanger et al., 1977) combined with cloning of small fragments of DNA in a single-stranded DNA bacteriophage is described, determining the 2771-nucleotide sequence of the largest MboI restriction enzyme fragment from human mitochondrial DNA.
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Progressive sequence alignment as a prerequisite to correct phylogenetic trees.
Da-Fei Feng,Russell F. Doolittle +1 more
TL;DR: A progressive alignment method that utilizes the Needleman and Wunsch pairwise alignment algorithm iteratively to achieve the multiple alignment of a set of protein sequences and to construct an evolutionary tree depicting their relationship is described.
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DNA topoisomerase poisons as antitumor drugs.
TL;DR: Inhibition of DNA Synthesis, Inhibition of Cell Division, and Other CELLULAR RESPONSes and DRUG RESISTANCE are studied.