Journal ArticleDOI
A metal- and base-free domino protocol for the synthesis of 1,3-benzoselenazines, 1,3-benzothiazines and related scaffolds.
TLDR
The merits of the present methods rely on the easy access of rarely explored bioactive scaffolds like 1,3-benzoselenazine derivatives, for which well-documented methods are rarely known in the literature.Abstract:
Efficient protocols have been described for the synthesis of 1,3-benzoselenazines, 1,3-benzothiazines, 2-aryl thiazin-4-ones and diaryl[b,f][1,5]diazocine-6,12(5H,11H)-diones. These transformations were successfully driven towards the product formation under mild acid catalyzed reaction conditions at room temperature using 2-amino aryl/hetero-aryl alkyl alcohols and amides as substrates. The merits of the present methods also rely on the easy access of rarely explored bioactive scaffolds like 1,3-benzoselenazine derivatives, for which well-documented methods are rarely known in the literature. A broad range of substrates with both electron-rich and electron-deficient groups were well-tolerated under the developed conditions to furnish the desired products in yields up to 98%. The scope of the devised method is not only restricted to the synthesis of 1,3-benzoselenazines, but it was also further extended towards the synthesis of 1,3-benzothiazines, 1,3-benzothiazinones and the corresponding eight membered N-heterocycles such as diaryl[b,f][1,5]diazocine-6,12(5H,11H)-diones.read more
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Journal ArticleDOI
I2-Promoted Multicomponent Dicyclization and Ring-Opening Sequences: Direct Synthesis of Benzo[e][1,4]diazepin-3-ones via Dual C–O Bond Cleavage
TL;DR: A novel and efficient formal [4 + 2+1] annulation of aryl methyl ketones and 2-aminobenzyl alcohols for the synthesis of benzo[e][1,4]diazepin-3-ones is reported, which affords diverse seven-membered ring lactams via dual C-O bond cleavage.
Journal ArticleDOI
Reagent-Controlled Divergent Synthesis of 2-Amino-1,3-Benzoxazines and 2-Amino-1,3-Benzothiazines.
V. P. Rama Kishore Putta,Nagaraju Vodnala,Raghuram Gujjarappa,Ujjawal Tyagi,Aakriti Garg,Sreya Gupta,P. P. Pujar,Chandi C. Malakar +7 more
TL;DR: The described protocol represents as the first example for the synthesis of 4H-1,3-benzoxazines via dehydrosulfurization method using molecular iodine as reagent.
Journal ArticleDOI
Synthesis and biological activities of 4 h -3,1-benzothiazin-4-ones
Lan Phuong Vu,Michael Gütschow +1 more
TL;DR: A review of representative methods to generate 4H-3,1-benzothiazin-4-ones and the biological activities of the resulting products are highlighted in this article.
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