Journal ArticleDOI
A module of the DnaJ heat shock proteins found in malaria parasites
TLDR
The DnaJ family shows typical features of mosaic proteins 9 which contain different building units (modules) with separate functions, and a surprising similarity to the ring-infected erythrocyte surface antigen of the malaria parasite Plasmodium falciparum.About:
This article is published in Trends in Biochemical Sciences.The article was published on 1992-04-01. It has received 89 citations till now. The article focuses on the topics: DNAJA2 & DNAJB1.read more
Citations
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Journal ArticleDOI
The Function of Heat-Shock Proteins in Stress Tolerance: Degradation and Reactivation of Damaged Proteins
D A Parsell,Susan Lindquist +1 more
TL;DR: The Lon Protease, DnaK.T URNOVER of AB ERR ANT PROT EINS in E. COLI, and more.
Journal ArticleDOI
Role of the Major Heat Shock Proteins as Molecular Chaperones
Costa Georgopoulos,W J Welch +1 more
Journal ArticleDOI
Chromosome 2 Sequence of the Human Malaria Parasite Plasmodium falciparum
Malcolm J. Gardner,Herve Tettelin,Daniel J. Carucci,Leda M. Cummings,L. Aravind,Eugene V. Koonin,Shamira J. Shallom,Tanya Mason,Kelly Yu,Claire Fujii,James Pederson,Kun Shen,Junping Jing,Christopher Aston,Zhongwu Lai,David C. Schwartz,Mihaela Pertea,Steven L. Salzberg,Lixin Zhou,Granger G. Sutton,Rebecca A. Clayton,Owen White,Hamilton O. Smith,Claire M. Fraser,Mark D. Adams,J. Craig Venter,Stephen L. Hoffman +26 more
TL;DR: Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes as discussed by the authors.
Journal ArticleDOI
Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites
Tobias Sargeant,Tobias Sargeant,Matthias Marti,Elisabet Caler,Jane M. Carlton,Ken M. Simpson,Terence P. Speed,Alan F. Cowman +7 more
TL;DR: Data suggest radiation of genes encoding remodeling and virulence factors from a small number of loci in a common Plasmodium ancestor, and imply a closer phylogenetic relationship between the P. vivax and P. falciparum lineages than previously believed.
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The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication.
TL;DR: It is demonstrated that the highly conserved NH2-terminal region of DnaJ, the so-called J region, is necessary and sufficient for stimulating both DnaK's ATPase activity and lambda-DNA replication.
References
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Journal ArticleDOI
Database of homology-derived protein structures and the structural meaning of sequence alignment.
Chris Sander,Reinhard Schneider +1 more
TL;DR: A database of homology‐derived secondary structure of proteins (HSSP) is produced by aligning to each protein of known structure all sequences deemed homologous on the basis of the threshold curve, effectively increasing the number of known protein structures by a factor of five to more than 1800.
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A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein.
TL;DR: Conditional- lethal mutants (npl, for nuclear protein localization) that missorted NLS-cytochrome c1 to the mitochondria, allowing growth on glycerol are isolated and may act at a very early common step in localization of proteins to the nucleus and the ER.
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Characterization of YDJ1: a yeast homologue of the bacterial dnaJ protein.
TL;DR: It is shown that a related yeast protein, SIS1, is a multicopy suppressor of Y DJ1, and localization of YDJ1 protein by indirect immunofluorescence reveals it to be concentrated in a perinuclear ring as well as in the cytoplasm.
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Immune sera recognize on erythrocytes a Plasmodium falciparum antigen composed of repeated amino acid sequences
Ross L. Coppel,Alan F. Cowman,Robin F. Anders,Albert Edward Bianco,Robert Saint,Klaus R. Lingelbach,David James Kemp,Graham Brown +7 more
TL;DR: It is shown that antibodies against the fused polypeptide expressed by one such clone react with a P. falciparum protein that is synthesized late in schizogony and is later present on the surface of the ring-infected erythrocyte.