A-Myb Up-regulates Bcl-2 through a Cdx Binding Site in t(14;18) Lymphoma Cells
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It is shown that A-Myb up-regulates bcl-2promoter activity and Mutagenesis of the Cdx binding site abolished binding by the 32-kDa protein and significantly reduced the ability of A- myb to induce bCl-2 expression.About:
This article is published in Journal of Biological Chemistry.The article was published on 2000-03-03 and is currently open access. It has received 65 citations till now. The article focuses on the topics: MYB & Expression vector.read more
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Methods and compositions for cancer therapy
TL;DR: In this paper, an oligonucleotide-based approach was proposed for the inhibition of oncogenes involved in cancers, which was shown to be effective in the treatment of cancer.
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Transcriptional Regulation of Apoptosis
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Contrasting roles for G-quadruplexes in regulating human Bcl-2 and virus homologues KSHV KS-Bcl-2 and EBV BHRF1
Shivani Kumar,Chitteti Ramamurthy,Divya Choudhary,Aashika Sekar,Anupam Patra,Neel Sarovar Bhavesh,Perumal Vivekanandan +6 more
TL;DR: In this paper , the role of G-quadruplexes in the regulatory regions of viral Bcl2 homologues encoded by KSHV (KS-Bcl-2) and EBV (BHRF1).
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Expression Analysis of Several Lymphoma-specific Genes in Human Fibroblasts Immortalized with SV40
V V Nenasheva,A. I. Nikolaev,V. I. Dubovaya,L. S. Inozemtseva,E. S. Manuilova,A. V. Martynenko,Vyacheslav Z. Tarantul +6 more
TL;DR: In this article, the level of gene transcription in two human fibroblast lines and in their derivatives immortalized with either a temperature-sensitive mutant of SV-40 or with pSV3neo carrying the SV40 А gene, considering the latter as a model of early cell malignant transformation.
References
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Journal ArticleDOI
Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
TL;DR: The results suggest that t(14;18) translocations alter expression of the bcl-2 gene both by transcriptional activation and by abnormal posttranscriptional regulation of bCl-2 mRNA.
Journal ArticleDOI
The Chromosomal Basis of Human Neoplasia
TL;DR: It is proposed that chromosomal rearrangements play a central role in human neoplasia and may exert their effects through related genomic mechanisms and a translocation could serve to place an oncogene next to an activating DNA sequence, a deletion to eliminate anOncogene repressor, and trisomy to carry extra gene dosage.
Journal Article
Identification of a p53-dependent negative response element in the bcl-2 gene
TL;DR: The results demonstrate the existence of a negative response element in the bcl-2 gene through which p53 may either directly or indirectly transcriptionally down-regulate expression of this gene involved in the regulation of programmed cell death.
Journal ArticleDOI
Homeosis and intestinal tumours in Cdx2 mutant mice.
TL;DR: The results suggest that Cdx2 mutation is the primary event in the genesis of some intestinal tumours.
Journal ArticleDOI
Viral myb oncogene encodes a sequence-specific DNA-binding activity.
TL;DR: It is shown that v-MYB specifically recognizes the nucleotide sequence pyAACG/TG, which seems to be a member of the class of sequence-specific DNA-binding factors presumably involved in gene regulation.