Journal ArticleDOI
A nationwide molecular epidemiological study on hepatitis B virus in Indonesia: identification of two novel subgenotypes, B8 and C7
Mulyanto,Sulaiman Ngongu Depamede,Kiely Surayah,Fumio Tsuda,Koji Ichiyama,Masaharu Takahashi,Hiroaki Okamoto +6 more
TLDR
The distribution of HBV genotypes/subgenotypes, including B8 and C7, seems to be associated with ethnological origins in Indonesia.Abstract:
Upon phylogenetic analysis of a partial S gene sequence [396 nucleotides (nt)], 928 hepatitis B virus (HBV) strains obtained from 899 viremic subjects in 28 major cities on 15 islands of Indonesia in 1989-2007 segregated into four HBV genotypes. Genotype B was predominant (66%), followed by genotype C (26%), genotype D (7%), and genotype A (0.8%). Comparative and phylogenetic analyses of the 396-nt S gene sequence of 928 HBV isolates and whole genomic sequences of 25 selected HBV isolates revealed a total of 14 subgenotypes within genotypes A-D: two (A1 and A2) in genotype A (HBV/A), five (B2, B3, B5, B7, and a novel subgenotype, tentatively designated B8) in HBV/B, five (C1, C2, C5, C6, and another novel subgenotype, C7) in HBV/C, and two (D1 and D3) in HBV/D. The distribution of HBV genotypes/subgenotypes, including B8 and C7, seems to be associated with ethnological origins in Indonesia.read more
Citations
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Hepatitis delta virus
TL;DR: Increased understanding of the molecular virology of HDV will identify novel therapeutic targets for this most severe form of chronic viral hepatitis, which is declining in some endemic areas but increasing in northern and central Europe because of immigration.
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Clinical relevance and public health significance of hepatitis B virus genomic variations
TL;DR: Examination of HBV mutations alone or in combination and host genetic susceptibility will be helpful in classifying the HBV-infected subjects who will develop HCC and need active anti-viral treatments.
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Molecular identification of hepatitis B virus genotypes/subgenotypes: revised classification hurdles and updated resolutions.
TL;DR: This review article aimed at highlighting potential pitfalls in genetic and phylogenetic analyses of HBV and suggest novel terms for HBV classification, including the term "immigro-subgenotype" to distinguish exotic (sub)genotypes from native ones and "recombino- subgenotype", which is proposed for many strains misclassified due to genetic differences resulting from recombination.
Journal ArticleDOI
Distribution and Hepatocellular Carcinoma-Related Viral Properties of Hepatitis B Virus Genotypes in Mainland China: A Community-Based Study
Jianhua Yin,Hongwei Zhang,Yongchao He,Jiaxin Xie,Shijian Liu,Wenjun Chang,Xiaojie Tan,Chunying Gu,Wei Lu,Hongyang Wang,Shengli Bi,Fuqiang Cui,Xiaofeng Liang,Stephan Schaefer,Guangwen Cao +14 more
TL;DR: HBV subgenotypes B2, C1, and C2 are endemic in Mainland China and HBV genotype C exhibits less replication activity in the young and harbors higher frequencies of the HCC-associated mutations than genotype B.
Journal ArticleDOI
Hepatitis B virus subgenotyping: History, effects of recombination, misclassifications, and corrections
Weifeng Shi,Zhong Zhang,Cheng Ling,Weimin Zheng,Chao-Dong Zhu,Michael J. Carr,Desmond G. Higgins +6 more
TL;DR: The recommendations currently employed for HBV subgenotyping are reviewed, the history of HBVSub genotyping, the effects of recombination on HBV SUB genotypes, misclassifications in HBVsubgenotypes, and suggestions are made to correct the misclassification.
References
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