Journal ArticleDOI
A new preparation method for dark-field electron microscopy of biomacromolecules.
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Preliminary observations on RNA polymerase attached to DNA suggest that the internal structures of the protein may be observed and that the enzyme is probably attached asymmetrically to the DNA.About:
This article is published in Journal of Ultrastructure Research.The article was published on 1971-04-01. It has received 352 citations till now. The article focuses on the topics: Dark field microscopy & Electron microscope.read more
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PatentDOI
Peptide nucleic acids
TL;DR: A peptide nucleic acid (PNA) as discussed by the authors is a class of compounds that can bind complementary ssDNA and RNA strands more strongly than a corresponding DNA, and it can be used to attach DNA bases to a peptide backbone through a suitable linker.
Journal ArticleDOI
Electron microscopic and biochemical evidence that chromatin structure is a repeating unit
TL;DR: Electron microscopic and biochemical studies demonstrate that the fundamental structure of chromatin depleted of lysine-rich histones is composed of a flexible chain of spherical particles (nucleosomes), about 125 A in diameter, connected by DNA filaments, suggesting that histone F1 is involved in the superpacking of DNA in chromosomes and nuclei.
Journal ArticleDOI
Proximity-Induced Superconductivity in DNA
A. Yu. Kasumov,A. Yu. Kasumov,Mathieu Kociak,Sophie Guéron,Bertrand Reulet,V. T. Volkov,Dmitry V. Klinov,Hélène Bouchiat +7 more
TL;DR: Results imply that DNA molecules can be conducting down to millikelvin temperature and that phase coherence is maintained over several hundred nanometers.
Journal ArticleDOI
Dependence of α-synuclein aggregate morphology on solution conditions
TL;DR: It is demonstrated that the morphology of a-synuclein aggregates is highly sensitive to solution conditions, implying that the fibrillar state does not necessarily represent the predominant or most functionally significant aggregated state under physiological conditions.
Journal ArticleDOI
Identification of a protein linked to the ends of adenovirus DNA
TL;DR: It is proposed that the protein functions during DNA replication by facilitating priming of the progeny strands, thus allowing the 5′ ends of the DNA to be replicated.
References
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Journal ArticleDOI
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
TL;DR: The present study arose from the observation that a more intense colour was sometimes produced if, instead of being heated at 1000 for 10 min., the reaction mixture was allowed to stand overnight at room temperature.
Book ChapterDOI
[125] Monolayer techniques in electron microscopy of nucleic acid molecules
TL;DR: This chapter discusses the monolayer techniques in electron microscopy of nucleic acid molecules and describes a method in which DNA or RNA of a bulk solution is transformed to a monomolecular layer, using a film of protein floated onto an aqueous solution.
Journal ArticleDOI
Darstellung und längenmessungen des gesamten desoxyribonucleinsäure-inhaltes von T2-bakteriophagen
TL;DR: Electron micrographs of DNA macromolecules are prepared by spreading a suitable protein-salt solution with T2 phages to a mixed monolayer on a water-air interface and the first data of an average T2-DNA length of 49±4 μ are discussed in relation to the possible sources of error.
Journal ArticleDOI
The relation between the synthesis of deoxyribonucleic acid and the synthesis of protein in the multiplication of bacteriophage T2.
Journal ArticleDOI
Notizen: Zur Defokussierungsabhängigkeit des Phasenkontrastes bei der elektronenmikroskopischen Abbildung
TL;DR: In this article, a resultierende Stromdichteverteilung in den Ebenen hinter dem Objekt fand, daß jeder F O U R I R I E R K O I I I ponente der im objekt vorliegenden räumlichen Verteilund des inneren Potentials eine Ebene im Abstand Az unmittelbar hinter a nd ebenen zugeordnet werden kann, in der eine stromd