A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk
Jeanine M. Genkinger,Donna Spiegelman,Kristin E. Anderson,Leslie Bernstein,Piet A. van den Brandt,Eugenia E. Calle,Dallas R. English,Aaron R. Folsom,Jo L. Freudenheim,Charles S. Fuchs,Charles S. Fuchs,Graham G. Giles,Edward Giovannucci,Pamela L. Horn-Ross,Susanna C. Larsson,Michael F. Leitzmann,Michael F. Leitzmann,Satu Männistö,James R. Marshall,Anthony B. Miller,Alpa V. Patel,Thomas E. Rohan,Rachael Z. Stolzenberg-Solomon,Bas A.J. Verhage,Jarmo Virtamo,Bradley J. Willcox,Bradley J. Willcox,Alicja Wolk,Regina G. Ziegler,Stephanie A. Smith-Warner +29 more
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In this article, a pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up and a positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95% CI = 109-1.78).Abstract:
Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2) , pancreatic cancer risk was 47% higher (95%CI:23-75%) among obese (BMI ≥ 30 kg/m(2) ) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI ≥ 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2) ). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m(2) ) and not obese at baseline (BMI < 30 kg/m(2) ), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI ≥ 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.read more
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Body Fatness and Cancer — Viewpoint of the IARC Working Group
Béatrice Lauby-Secretan,Chiara Scoccianti,Dana Loomis,Yann Grosse,Franca Bianchini,Kurt Straif +5 more
TL;DR: The International Agency for Research on Cancer convened a workshop on the relationship between body fatness and cancer, from which an IARC handbook on the topic will appear.
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The Epidemiology of Pancreatitis and Pancreatic Cancer
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TL;DR: Alcohol abstinence and smoking cessation can alter the progression of pancreatitis and reduce recurrence; smoking cessation is the most effective strategy to reduce the risk of pancreatic cancer.
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Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors.
TL;DR: Up-to-date statistics on pancreatic cancer occurrence and outcome along with a better understanding of the etiology and identifying the causative risk factors are essential for the primary prevention of this disease.
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Epidemiology of pancreatic cancer
Milena Ilic,Irena Ilic +1 more
TL;DR: There are no current screening recommendations for pancreatic cancer, so primary prevention is of utmost importance and a better understanding of the etiology and identifying the risk factors is essential for the primary prevention of this disease.
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Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose–response meta-analysis of prospective studies
Dagfinn Aune,Darren C. Greenwood,D.S.M. Chan,R. Vieira,A.R. Vieira,D. A. Navarro Rosenblatt,Janet E Cade,Victoria J. Burley,Teresa Norat +8 more
TL;DR: Both general and abdominal fatness increases pancreatic cancer risk and among nonsmokers, risk increases even among persons within the normal BMI range, even within the 'normal' BMI range.
References
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Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective
Michael Marmot,T. Atinmo,Tim Byers,J Chen,T Hirohata,Alan Jackson,W. P. T. James,L Kolonel,Shiriki K. Kumanyika,C Leitzmann,Jim Mann,H Powers,K.S. Reddy,Elio Riboli,JA Rivera,Arthur Schatzkin,Jacob C. Seidell,D Shuker,Ricardo Uauy,Walter C. Willett,Steven H. Zeisel +20 more
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TL;DR: In this article, the authors explore the extent to which food, nutrition, physical activity, and body composition modify the risk of cancer, and specify which factors are most important for cancer prevention.