A review of the anticancer activity of Azadirachta indica (Neem) in oral cancer.
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TLDR
The anticancer properties of neem were evaluated and the active constituents of Neem have been demonstrated to unequivocally have preventive and therapeutic potential against oral cancer.Abstract:
Background Azadirachta indica (neem), belongs to the family of Meliaceae plants, is found in the Indian subcontinent. The neem tree is colloquially referred to as the village pharmacy due to its array of biological properties. Every part of the neem tree like its bark, leaves, sap, fruit, seeds, and twigs find a multitude of uses. It is customary to use them for management of skin diseases and various other infections. The anticancer properties of neem have been studied in the past and these include its ability to modulate the tumour environment, increase the cytotoxic ability of host monocytes and suppress the proliferation of tumour cells. The present review was conducted with the objective of scrutinizing and assimilating data about the usefulness Azadirachta indica in oral cancer from all the previously done work. Material and methods A planned review was conducted of all the studies that investigated the role of Azadirachta indica in oral cancer. Literature search was carried out using PubMed, Scopus and Google scholar databases. In addition to electronic searching, hand searching, cross referencing and various internet engines were also used to collect data. The articles were perused and articles not pertinent to our search were omitted. Results and conclusion The anticancer properties of neem were evaluated and the active constituents of neem have been demonstrated to unequivocally have preventive and therapeutic potential against oral cancer. Although, greater exploration of the anticancer properties of neem are required in order to effectively integrate it into the routine management of oral cancer.read more
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Nimbolide, a Neem Limonoid, Is a Promising Candidate for the Anticancer Drug Arsenal.
TL;DR: Nimbolide, a major limonoid constituent of Azadirachta indica, commonly known as neem, has attracted increasing research attention owing to its wide spectrum of pharmacological properties, predominantly anticancer activity as mentioned in this paper.
Journal ArticleDOI
GCMS Profile of Bioactive Secondary Metabolites with Therapeutic Potential in the Ethanolic Leaf Extracts of Azadirachta indica¬: A Sacred Traditional Medicinal Plant of INDIA
TL;DR: Though it has been confirmed that neem and its constituents play role in the scavenging of free radical and prevention of disease pathogenesis, a clear scientific basis of its pharmacoinformatics is still lacking.
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Terpenoids from Azadirachta indica are potent inhibitors of Akt: Validation of the anticancer potentials in hepatocellular carcinoma in male Wistar rats
Oluseyi Adeboye Akinloye,Dorcas Ibukun Akinloye,Mariam A Lawal,Mujidat T Shittu,Damilohun Samuel Metibemu,Damilohun Samuel Metibemu +5 more
TL;DR: Terpenoids from Azadirachta indica are potent inhibitors of Akt and hitherto demonstrate anticancer potentials in hepatocellular carcinoma in male Wistar rats.
References
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Journal Article
Biological activities and medicinal properties of neem (Azadirachta indica)
TL;DR: This review gives a bird’s eye view mainly on the biological activities of some of the neem compounds isolated, pharmacological actions ofThe neem extracts, clinical studies and plausible medicinal applications of neem along with their safety evaluation.
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Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway
Perumal Elumalai,D.N. Gunadharini,Kalimuthu Senthilkumar,Sivanantham Banudevi,R. Arunkumar,Chellakkan Selvanesan Benson,G. Sharmila,Jagadeesan Arunakaran +7 more
TL;DR: It is suggested that nimbolide exhibit anticancer effect through its apoptosis-inducing property, and raises new hope for its use in anticancer therapy.
Journal ArticleDOI
Tumor microenvironment: a main actor in the metastasis process.
Daniela Spano,Massimo Zollo +1 more
TL;DR: A summary of the "state of the art" of the functions and actions of tumorigenic cells, as the main actors in the promotion of the formation of the microenvironment of the metastatic niche, and the associated network of interactions is undertaken.
Journal ArticleDOI
The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis.
G. Harish Kumar,R. Vidya Priyadarsini,Govindarajah Vinothini,P. Vidjaya Letchoumy,Siddavaram Nagini +4 more
TL;DR: Results provide compelling evidence that azadirachtin and nimbolide mediate their antiproliferative effects by downregulating proteins involved in cell cycle progression and transduce apoptosis by both the intrinsic and extrinsic pathways.
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Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model.
Jaganathan Kowshik,Rajakishore Mishra,Josephraj Sophia,Satabdi Rautray,Kumaraswamy Anbarasu,G. Deepak Reddy,Madhulika Dixit,Sundarasamy Mahalingam,Siddavaram Nagini +8 more
TL;DR: Findings provide compelling evidence that targeting RECK, a keystone protein that regulates mediators of invasion and angiogenesis with phytochemicals such as nimbolide may be a robust therapeutic approach to prevent oral cancer progression.