Journal ArticleDOI
A Review on Pharmacological and Analytical Aspects of Naringenin
TLDR
Detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future.Abstract:
Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits (grapefruit and oranges) and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders.read more
Citations
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Flavonoids in Cancer and Apoptosis.
Mariam Abotaleb,Samson Mathews Samuel,Elizabeth Varghese,Sharon Varghese,Peter Kubatka,Alena Liskova,Dietrich Büsselberg +6 more
TL;DR: A summary of flavonoids and their effectiveness in cancer treatment targeting apoptosis has been discussed and their high bioavailability, safety, minimal side effects and cost effectiveness are discussed.
Journal ArticleDOI
Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels
TL;DR: The aim of this review is to summarize the current knowledge addressing the antidiabetic effects of dietary flavonoids and their underlying molecular mechanisms on selected pathways: Glucose transporter, hepatic enzymes, tyrosine kinase inhibitor, AMPK, PPAR, and NF-κB.
Journal ArticleDOI
Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin.
TL;DR: This review focuses on the anti-inflammatory actions of flavonoids against chronic illnesses such as cancer, diabetes, cardiovascular diseases, and neuroinflammation with a special focus on apigenin, a relatively less toxic and non-mutagenic flavonoid with remarkable pharmacodynamics.
Journal ArticleDOI
Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update.
TL;DR: This review provides highlights of Naringenin with respect to its distribution, pharmacokinetic and its use in conditions like oxidative stress, inflammation, cancer, diabetes, cardiovascular diseases and neurological disorders.
Journal ArticleDOI
Antioxidants in liver health
Sael Casas-Grajales,Pablo Muriel +1 more
TL;DR: The objective of this review is to provide information pertaining to various antioxidants found in food that have demonstrated utility in improving liver diseases.
References
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Journal ArticleDOI
Antioxidant and prooxidant properties of flavonoids.
TL;DR: The aim of this review is to discuss both the antioxidant and prooxidant effects of flavonoids.
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Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.
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Journal ArticleDOI
Flavonoids as Nutraceuticals: A Review
TL;DR: In this article, the authors proposed a structure-classification method for plant phenolic compounds, namely, Bioflavonoids, for predicting and controlling food quality, and showed that a better understanding of their structures and biological activities indicates their potentials as therapeutic agents and also for predicting food quality.
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Investigation of the interaction between flavonoids and human serum albumin
Shuyun Bi,Shuyun Bi,Shuyun Bi,Lan Ding,Yuan Tian,Daqian Song,Xin Zhou,Xia Liu,Hanqi Zhang,Hanqi Zhang +9 more
TL;DR: In this paper, the interaction of quercetin, rutin, hyperin, and baicalin with human serum albumin (HSA) was studied, and the effect of various metal ions on the binding constants of these compounds with HSA was also studied.
Journal ArticleDOI
Modification of flavonoid biosynthesis in crop plants.
TL;DR: This review describes the current knowledge of the molecular regulation of the flavonoid pathway and the state of the art with respect to metabolic engineering of this pathway in crop plants.