Journal ArticleDOI
A run for a membrane vitamin D receptor.
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TLDR
A brief description of a search for a putative mVDR that lasted for over a decade is provided, which indicates that there are two mechanisms of the molecular mode-of-action of 1,25-dihydroxyvitamin D3.Abstract:
1,25-Dihydroxyvitamin D3 is the hormonally active form of vitamin D3. Its involvement in regulation of calcium and phosphate homeostasis as well as in differentiation and regulatread more
Citations
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Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts.
TL;DR: The availability of 1,25(OH)(2)D(3) analogs with immunomodulatory activity at non-hypercalcemic doses may allow exploitation of their immunommodulatory effects in a clinical setting of treatment of autoimmune diseases and prevention of allograft rejection.
Journal ArticleDOI
Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells.
Audreesh Banerjee,Gautam Damera,R Bhandare,Shi Gu,Y S Lopez-Boado,Reynold A. Panettieri,Omar Tliba +6 more
TL;DR: Investigation of whether 1α, 25‐dihydroxy vitamin D3 (calcitriol) modulated chemokine production in ASM found it to be a potential source of chemokines for asthma patients.
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Vitamin D and asthma
TL;DR: Vitamin D is discussed as it relates to asthma across the age spectrum, with a focus on human studies, since vitamin D concentrations decrease with increased time spent indoors, decreased exposure to sunlight, less exercise, obesity, and inadequate calcium intake.
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Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice
TL;DR: The primary and secondary lymphoid organs in DKO mice are profoundly altered as a consequence of the fulminating inflammation in the gastrointestinal tract.
Journal ArticleDOI
Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials.
TL;DR: Evidence from RCTs do support an effect of vitamin D supplements on muscle strength and function in the elderly, but more studies showing a lack of an effect have been published than studies showing beneficial effects.
References
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Journal ArticleDOI
The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
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Current Understanding of the Molecular Actions of Vitamin D
TL;DR: This review raises the intriguing question of whether vitamin D plays an important role in embryonic development, since vitamin D deficiency does not prohibit development, nor does vitamin D receptor knockout.
Journal ArticleDOI
Structure-Function Relationships in the Vitamin D Endocrine System*
TL;DR: There is evidence that the hormonally active form of vitamin D, 1α, 25-dihydroxyvitamin D3 [1α,25(OH)2D3], may generate biological responses via both regulation of gene transcription as well as via nongenomic pathways, some of which involve opening of voltage-gated Ca2+ channels.
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Cloning and expression of full-length cDNA encoding human vitamin D receptor.
Andrew R. Baker,Donald P. McDonnell,M. R. Hughes,T. M. Crisp,David J. Mangelsdorf,Mark R. Haussler,J W Pike,John Shine,Bert W. O'Malley +8 more
TL;DR: Sequence comparisons demonstrate that the vitamin D receptor belongs to the steroid-receptor gene family and is closest in size and sequence to another member of this family, the thyroid hormone receptor.
Journal ArticleDOI
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
Dario R. Alessi,Y. Saito,David G. Campbell,Philip Cohen,G. Sithanandam,U. Rapp,A. Ashworth,C.J. Marshall,Sally A. Cowley +8 more
TL;DR: Analysis of MAPKK1 mutants in which either Ser217 or Ser221 were changed to glutamic acid, and the finding that inactivation of maximally activatedMAPKK1 required the dephosphorylated of both serines, shows that phosphorylation of either residue is sufficient for maximal activation.
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1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation
Giuseppe Penna,Luciano Adorini +1 more