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A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice

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TLDR
Experimental transmission evidence indicated that both the neurologic and lymphomatous disorders almost certainly were caused by the indigenous type-C virus.
Abstract
Abstract A high incidence of spontaneous lower-limb paralysis occurred in a population of wild mice (Mus musculus) which had a high incidence of naturally occurring lymphoma and elevated indigenous type-C virus activity. Experimental transmission evidence indicated that both the neurologic and lymphomatous disorders almost certainly were caused by the indigenous type-C virus. The virus appeared to have a direct neurotropic effect on anterior horn neurons in the lower spinal cord.

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HTLV-III infection in brains of children and adults with AIDS encephalopathy

TL;DR: Brains from 15 individuals with AIDS and encephalopathy were examined by Southern analysis and in situ hybridization for the presence of human T-cell leukemia (lymphotropic) virus type III (HTLV-III), the virus believed to be the causative agent of AIDS.
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In vivo delivery of miRNAs for cancer therapy: challenges and strategies.

TL;DR: This review discusses the key challenges to the development of the carriers for miRNA-based therapy and explores current strategies to systemically deliver miRNAs to cancer without induction of toxicity.
Journal ArticleDOI

On immunological memory.

TL;DR: In the absence of an immune response, mothers protect their offspring during a critical immunoincompetent period (a consequence of MHC-restricted T cell recognition) by passive transfer of neutralizing antibodies as discussed by the authors.
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Induction of Protective CTL Responses in Newborn Mice by a Murine Retrovirus

TL;DR: The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response, suggesting the initial viral dose is critical in the development of protective immunity in newborns.
Journal ArticleDOI

Naturally occurring murine leukemia viruses in wild mice: characterization of a new "amphotropic" class.

J W Hartley, +1 more
- 01 Jul 1976 - 
TL;DR: A new class of murine leukemia viruses, isolated from wild Mus musculus trapped in California, is described, designated "amphotropic," which replicate in mouse, rabbit, mink, human, guinea pig, and rat cells, but not in hamster, quail, or duck cells.
References
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Journal ArticleDOI

Mutant Mice (Quaking and Jimpy) with Deficient Myelination in the Central Nervous System

TL;DR: Quaking is a new autosomal recessive mutant mouse with marked tremor of the hindquarters and Jimpy, a known sex-linked mutation, has similar but more severe symptoms and similar pathology, with the additional feature of sudanophilic (nonpolar) lipid distributed in some white-matter tracts.
Journal ArticleDOI

RD-114 virus compared with feline and murine type-C viruses released from RD cells.

TL;DR: In an effort to rescue components of a hypothetical human sarcoma virus genome, a human rhabdomyosarcoma cell line was infected with the GA strain of FeLV or the rat-tropic Kirsten strain of murine sarcomA virus and virus productive cell lines were established.
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