A Standardized Assessment of Thyroid Nodules in Children Confirms Higher Cancer Prevalence Than in Adults
Anjuli Gupta,Samantha Ly,Luciana A. Castroneves,Mary C. Frates,Carol B. Benson,Henry A. Feldman,Ari J. Wassner,Jessica Smith,Ellen Marqusee,Erik K. Alexander,Justine A. Barletta,Peter M. Doubilet,Hope E. Peters,Susan M. Webb,Biren P. Modi,Harriet J. Paltiel,Harry P.W. Kozakewich,Edmund S. Cibas,Francis D. Moore,Robert C. Shamberger,P. Reed Larsen,Stephen A. Huang +21 more
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TLDR
Although the relative cancer prevalence of sonographically confirmed nodules ≥ 1 cm is higher in pediatric patients than adults, most children referred for suspected nodules have benign conditions, and efforts to avoid unnecessary surgery in this majority are warranted.Abstract:
Context: Thyroid cancer is the most common endocrine malignancy, but due to its rare occurrence in the pediatric population, the cancer risk of childhood thyroid nodules is incompletely defined, and optimal management of children with suspected nodules is debated. Objective: The aim was to study the presenting features and cancer risk of sporadic childhood thyroid nodules using a standardized clinical assessment and management plan. Design and Setting: Boston Children's Hospital and Brigham and Women's Hospital collaborated to create a multidisciplinary pediatric thyroid nodule clinic and implement a standardized assessment plan. Upon referral for a suspected nodule, serum TSH was measured and hypothyrotropinemic patients underwent 123I scintigraphy. All others underwent thyroid ultrasonography, and if this confirmed nodule(s) ≥ 1 cm, ultrasound-guided fine-needle aspiration was performed. Medical records were retrospectively reviewed and compared to a control population of 2582 adults evaluated by identi...read more
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Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Gary L. Francis,Steven G. Waguespack,Andrew J. Bauer,Peter Angelos,Salvatore Benvenga,Janete M. Cerutti,Catherine A. Dinauer,Jill Hamilton,Ian D. Hay,Markus Luster,Marguerite T. Parisi,Marianna Rachmiel,Geoffrey B. Thompson,Shunichi Yamashita +13 more
TL;DR: These inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules.
Journal ArticleDOI
Thyroid Disorders in Children and Adolescents: A Review
TL;DR: A practical review of the presentation, evaluation, and treatment of thyroid disorders commonly encountered in a primary care practice is provided to provide evidence-based management practices for the clinician, as well as consensus statements and guidelines.
Journal ArticleDOI
Predictors of Malignancy in Children with Thyroid Nodules.
Alessandro Mussa,Maurilio De Andrea,Manuela Motta,Alberto Mormile,Nicola Palestini,Andrea Corrias +5 more
TL;DR: Clinical, laboratory, and US features of nodules can be used as predictors of malignancy in children, and although none has diagnostic accuracy as high as that of fine-needle aspiration biopsy, these predictors should be considered in deciding the diagnostic approach of children with thyroid nodules.
Journal ArticleDOI
Molecular Characterization of Sporadic Pediatric Thyroid Carcinoma with the DNA/RNA ThyroSeq v2 Next-Generation Sequencing Assay
Jennifer Picarsic,Melissa Buryk,John A. Ozolek,Sarangarajan Ranganathan,Sara E. Monaco,Jeffrey P. Simons,Selma F. Witchel,Nursen Gurtunca,Judith M. Joyce,Shan Zhong,Marina N. Nikiforova,Yuri E. Nikiforov +11 more
TL;DR: The data support the use of broad gene panels for the molecular diagnostics of pediatric thyroid nodules to aid future classification, treatment, and clinical management recommendations, and additional work is needed to investigate if pediatric DTCs could benefit from a reclassification based on molecular subtypes, which may better reflect their underlying biologic potential.
Journal ArticleDOI
Comprehensive Survey Results of Childhood Thyroid Ultrasound Examinations in Fukushima in the First Four Years After the Fukushima Daiichi Nuclear Power Plant Accident
Shinichi Suzuki,Satoru Suzuki,Toshihiko Fukushima,Sanae Midorikawa,Hiroki Shimura,Takashi Matsuzuka,Tetsuo Ishikawa,Hideto Takahashi,Akira Ohtsuru,Akira Sakai,Mitsuaki Hosoya,Seiji Yasumura,Kenneth E. Nollet,Tetsuya Ohira,Hitoshi Ohto,Masafumi Abe,Kenji Kamiya,Kenji Kamiya,Shunichi Yamashita,Shunichi Yamashita +19 more
TL;DR: The high prevalence of childhood thyroid cancer detected in this four-year study in Fukushima can be attributed to mass screening and clearly exceeds what is found incidentally anywhere else.
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The Bethesda System for Reporting Thyroid Cytopathology.
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The Bethesda System for Reporting Thyroid Cytopathology
Edmund S. Cibas,Syed Z. Ali +1 more
TL;DR: The conclusions regarding terminology and morphologic criteria from the NCI meeting led to the Bethesda Thyroid Atlas Project and form the framework for The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), a flexible framework for communication and research into thyroid diseases.