Journal ArticleDOI
Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain
Hui Jun Wu,Wei Wu,Hai Ying Sun,Guo-Wei Qin,Hong-Bing Wang,Panwen Wang,Hari Krishna Yalamanchili,Junwen Wang,Hung-Fat Tse,Chu-Pak Lau,Paul M. Vanhoutte,Gui-Rong Li +11 more
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TLDR
The novel information that acacetin mainly blocks open hKv1.5 channels by binding to their S6 domain is demonstrated, which is beneficial for anti-atrial fibrillation.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2011-12-01. It has received 41 citations till now. The article focuses on the topics: Acacetin & Ion channel blocker.read more
Citations
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Journal ArticleDOI
Novel molecular targets for atrial fibrillation therapy
TL;DR: This Review focuses on the mechanistic rationale for the development of new anti-atrial fibrillation drugs, on the molecular and structural motifs that they target and on the results obtained so far in experimental and clinical studies.
Journal ArticleDOI
The beneficial health effects of flavonoids on the cardiovascular system: Focus on K+ channels
TL;DR: Detailed analysis of the flavonoid potential, direct/indirect modulation of cardiovascular K+ channels is presented as these natural compounds ingested with the diet, despite extensive gut metabolism, may accumulate at cellular level in the form of the parent aglycones.
Journal ArticleDOI
The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway.
Wei-Yin Wu,Yun-Da Li,Yu-Kai Cui,Chan Wu,Yi-Xiang Hong,Gang Li,Yao Wu,Ling-Jun Jie,Yan Wang,Gui-Rong Li +9 more
TL;DR: The results demonstrate for the first time that AMPK-mediated Nrf2 activation is involved in the cardiomyocytes protection of acacetin against hypoxia/reoxygenation injury by activating a series of intracellular signals involved in anti-oxidation, anti-inflammation, and anti-apoptosis.
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Acacetin blocks kv1.3 channels and inhibits human T cell activation
TL;DR: Conclusions: Acacetin blocks the Kv1.3 channel and inhibits human T cell activation, which most likely contributes to its immunomodulatory and anti-inflammatory actions.
Journal ArticleDOI
Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.
Wei Wu,Michael C. Sanguinetti +1 more
TL;DR: A general overview of the mechanistic and structural basis of ion selectivity, gating, and pharmacology of the 3 types of cardiac delayed rectifier potassium ion channels is provided.
References
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Journal ArticleDOI
Impact of Atrial Fibrillation on the Risk of Death The Framingham Heart Study
Emelia J. Benjamin,Philip A. Wolf,Ralph B. D'Agostino,Halit Silbershatz,William B. Kannel,Daniel Levy +5 more
TL;DR: There was a significant AF-sex interaction: AF diminished the female advantage in survival and AF remained significantly associated with excess mortality, with about a doubling of mortality in both sexes in subjects free of valvular heart disease and preexisting cardiovascular disease.
Journal ArticleDOI
Lifetime risk for development of atrial fibrillation: the Framingham Heart Study.
Donald M. Lloyd-Jones,Thomas J. Wang,Thomas J. Wang,Eric P. Leip,Eric P. Leip,Martin G. Larson,Martin G. Larson,Daniel Levy,Daniel Levy,Ramachandran S. Vasan,Ramachandran S. Vasan,Ralph B. D'Agostino,Ralph B. D'Agostino,Joseph M. Massaro,Joseph M. Massaro,Alexa S. Beiser,Alexa S. Beiser,Philip A. Wolf,Philip A. Wolf,Philip A. Wolf,Emelia J. Benjamin,Emelia J. Benjamin +21 more
TL;DR: Lifetime risks for development of AF are 1 in 4 for men and women 40 years of age and older, even in the absence of antecedent congestive heart failure or myocardial infarction, and substantial lifetime risks underscore the major public health burden posed by AF.
Journal ArticleDOI
Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study.
Thomas J. Wang,Martin G. Larson,Martin G. Larson,Daniel Levy,Daniel Levy,Ramachandran S. Vasan,Ramachandran S. Vasan,Eric P. Leip,Philip A. Wolf,Philip A. Wolf,Ralph B. D'Agostino,Ralph B. D'Agostino,Joanne M. Murabito,Joanne M. Murabito,William B. Kannel,William B. Kannel,Emelia J. Benjamin,Emelia J. Benjamin +17 more
TL;DR: Individuals with AF or CHF who subsequently develop the other condition have a poor prognosis, and additional studies addressing the pathogenesis, prevention, and optimal management of the joint occurrence of AF and CHF appear warranted.
Journal ArticleDOI
Epidemiology and natural history of atrial fibrillation: clinical implications.
TL;DR: An understanding of the epidemiology and natural history of AF is crucial to the future allocation of resources and the utilization of an expanding range of therapies aimed at reducing the impact of this disease on a changing patient population.
Journal ArticleDOI
Evidence for Two Components of Delayed Rectifier K+ Current in Human Ventricular Myocytes
TL;DR: It is concluded that a functionally significant IK, with components corresponding to IKr and IKs, is present in human ventricular cells, whereas IKur appears to be absent.