Journal ArticleDOI
Accumulation of D-Aspartic Acid with Age in the Human Brain
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TLDR
Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.Abstract:
An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.read more
Citations
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Oxy-radicals and related species: their formation, lifetimes, and reactions.
TL;DR: In this brief overview of the ways in which free radicals and related highly reactive species are produced in biological systems, the reactivities and lifetimes of these species are discussed, and some pathological conditions and chronic diseases in which these species may be involved are briefly listed.
Journal ArticleDOI
Effect of collagen turnover on the accumulation of advanced glycation end products.
Nicole Verzijl,Jeroen DeGroot,Suzanne R. Thorpe,Ruud A. Bank,J. Nikki Shaw,Timothy J. Lyons,Johannes W. J. Bijlsma,Floris P J G Lafeber,John W. Baynes,Johan M. TeKoppele +9 more
TL;DR: First experimental evidence that protein turnover is a major determinant in AGE accumulation in different collagen types is provided, thereby providing the first reasonable estimates of the half-lives of these collagens.
Journal ArticleDOI
Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon.
TL;DR: The results indicate that airspace enlargement characteristic of "aging lung" is not associated with appreciable new synthesis of lung parenchymal elastin, and provides a foundation for strategies to directly evaluate extracellular matrix injury and repair in diseases of lung, vascular tissue, and skin.
Journal ArticleDOI
Age estimation: the state of the art in relation to the specific demands of forensic practise.
Stefanie Ritz-Timme,Cristina Cattaneo,Matthew J. Collins,E. R. Waite,H. W. Schütz,H. J. Kaatsch,Helene Borrman +6 more
TL;DR: Here a biochemical method based on aspartic acid racemization in dentine provides the most accurate estimates of age, followed by special morphological dental and skeletal methods.
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Endogenous d‐Serine in Rat Brain: N‐Methyl‐d‐Aspartate Receptor‐Related Distribution and Aging
TL;DR: It is proposed that d‐serine is a novel candidate as an intrinsic ligand for the glycine site in mammalian brain, which is closely correlated with those of the N‐methyl‐d‐aspartate‐type excitatory amino acid receptor.
References
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Journal ArticleDOI
Aspartic acid racemisation in the human lens during ageing and in cataract formation
TL;DR: Results are reported here the results of D/L enantiomeric analyses of normal human lenses and cataracts: aspartic acid racemisation was seen during ageing andCataract formation.
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Aspartic acid racemisation in dentine as a measure of ageing.
TL;DR: It is shown that tooth dentine is a more suitable material, and the extent of aspartic acid racemisation in this fraction can be used as a reliable indicator of mammalian age.
Journal ArticleDOI
Aspartic acid racemization in tooth enamel from living humans.
TL;DR: The rate constant for the racemization reaction of aspartic acid in human tooth enamel was found to be 8.29 X 10(-4) yr-1, suggesting that in any protein with a long in vivo lifetime, D-aspartic Acid will accumulate with age.