Acellular nerve allografts in peripheral nerve regeneration: A comparative study
Amy M. Moore,Matthew R. MacEwan,Katherine B. Santosa,Kristofer E. Chenard,Wilson Z. Ray,Daniel A. Hunter,Susan E. Mackinnon,Philip J. Johnson +7 more
TLDR
Findings provide evidence that differential processing for removal of cellular constituents in preparing acellular nerve allografts affects recovery in vivo.Abstract:
Introduction: Processed nerve allografts offer a promising alternative to nerve autografts in the surgical management of peripheral nerve injuries where short deficits exist Methods: Three established models of acellular nerve allograft (cold-preserved, detergent-processed, and AxoGen-processed nerve allografts) were compared with nerve isografts and silicone nerve guidance conduits in a 14-mm rat sciatic nerve defect Results: All acellular nerve grafts were superior to silicone nerve conduits in support of nerve regeneration Detergent-processed allografts were similar to isografts at 6 weeks postoperatively, whereas AxoGen-processed and cold-preserved allografts supported significantly fewer regenerating nerve fibers Measurement of muscle force confirmed that detergent-processed allografts promoted isograft-equivalent levels of motor recovery 16 weeks postoperatively All acellular allografts promoted greater amounts of motor recovery compared with silicone conduits Conclusion: These findings provide evidence that differential processing for removal of cellular constituents in preparing acellular nerve allografts affects recovery in vivo Muscle Nerve, 2011read more
Citations
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Biomaterials for the Development of Peripheral Nerve Guidance Conduits
TL;DR: Approaches to peripheral nerve repair through a channel or conduit are highlighted, implementing chemical and physical growth and guidance cues to direct that repair process.
Journal ArticleDOI
Functional outcome following nerve repair in the upper extremity using processed nerve allograft.
Mickey S. Cho,Brian Rinker,Renata V. Weber,Jerome D. Chao,John V. Ingari,Darrell Brooks,Gregory M. Buncke +6 more
TL;DR: The data suggest that processed nerve allografts offer a safe and effective method of reconstructing peripheral nerve gaps from 5 to 50 mm in length, and these outcomes compare favorably with those reported in the literature for nerve autograft, and exceed those reported for tube conduits.
Journal ArticleDOI
Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit
TL;DR: The present work overviews the current reports dealing with the several features that can be used to improve peripheral nerve regeneration (PNR), ranging from the simple use of hollow NGCs to tissue engineered intraluminal fillers, or to even more advanced strategies, comprising the molecular and gene therapies as well as cell-based therapies.
Journal ArticleDOI
Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence.
Maryam Saheb-Al-Zamani,Ying Yan,Scott J. Farber,Daniel A. Hunter,Piyaraj Newton,Matthew D. Wood,Sheila A. Stewart,Philip J. Johnson,Susan E. Mackinnon +8 more
TL;DR: Results are the first to suggest that SC senescence plays a role in limited axonal regeneration across nerve grafts of increasing gap lengths, as well as the presence of senescent SCs within both graft types.
Journal ArticleDOI
Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery.
Ghulam Hussain,Jing Wang,Azhar Rasul,Haseeb Anwar,Muhammad Qasim,Shamaila Zafar,Nimra Aziz,Aroona Razzaq,Rashad Hussain,Jose-Luis Gonzalez de Aguilar,Jose-Luis Gonzalez de Aguilar,Tao Sun +11 more
TL;DR: This review highlights detailed pathophysiological events after an injury to a peripheral nerve and the associated factors that can either hinder or promote the regenerative machinery.
References
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Journal ArticleDOI
Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries.
TL;DR: Motor vehicles crashes predominated as the cause of injury, and the most frequently injured nerve was the radial nerve, and in the lower limb, the peroneal nerve was most commonly injured.
Journal ArticleDOI
Identification of extractable growth factors from small intestinal submucosa.
Sherry L. Voytik-Harbin,Andrew O. Brightman,Meredith R. Kraine,Beverly Z. Waisner,Stephen F. Badylak +4 more
TL;DR: Identification of FGF‐2 and TGFβ‐related activities in SIS, two growth factors known to significantly affect critical processes of tissue development and differentiation, provides the opportunity to further elucidate the mechanisms by which this extracellular matrix biomaterial modulates wound healing and tissue remodeling.
Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.
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Spatial‐Temporal progress of peripheral nerve regeneration within a silicone chamber: Parameters for a bioassay
TL;DR: The spatial‐temporal progress of peripheral nerve regeneration across a 10‐mmgap within a silicone chamber was examined and the parameters of a morphologic assay for regeneration in this chamber model can be used to investigate cellular and molecular mechanisms underlying the success of peripheral nerves regeneration.
Journal ArticleDOI
Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans.
David B. Kantor,Onanong Chivatakarn,Katherine L. Peer,Stephen F. Oster,Masaru Inatani,Michael J. Hansen,John G. Flanagan,Yu Yamaguchi,David W. Sretavan,Roman J. Giger,Alex L. Kolodkin +10 more
TL;DR: It is shown that the transmembrane protein semaphorin 5A (Sema5A) is a bifunctional guidance cue exerting both attractive and inhibitory effects on developing axons of the fasciculus retroflexus, a diencephalon fiber tract associated with limbic function.