Journal ArticleDOI
Acetylcholine permits long-term enhancement of neuronal responsiveness in cat primary somatosensory cortex.
TLDR
It may be that the changes in responsiveness observed here following iontophoretically applied ACh are similar to those which facilitate the acquisition of neuronal responses to altered or novel afferent inputs.About:
This article is published in Neuroscience.The article was published on 1987-07-01. It has received 152 citations till now. The article focuses on the topics: Receptive field & Sensory stimulation therapy.read more
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Book
Brainstem control of wakefulness and sleep
TL;DR: A monograph communicating the current realities and future possibilities of unifying basic studies on anatomy and cellular physiology with investigations of the behavioral and physiological events of waking and sleep.
Journal ArticleDOI
Hebbian Synapses: Biophysical Mechanisms and Algorithms
TL;DR: The biophysical mechanism demonstrated in vitro to control the induction of one type of hippocampal LTP has been shown to satisfy the definition of a Hebbian synaptic modification, and a contemporary definition is suggested.
Journal ArticleDOI
Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase
M.-Marsel Mesulam,Changiz Geula +1 more
TL;DR: Conurrent histochemical and immunological staining demonstrated that all choline‐acetyltransferase‐positive NB neurons in the human brain also contain acetylcholinesterase enzyme activity, which justified the designation of these cholinergic neurons inThe human brain as the Ch4 (or NB‐Ch4) complex.
Journal ArticleDOI
Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo
Norio Takata,Tsuneko Mishima,Chihiro Hisatsune,Terumi Nagai,Etsuko Ebisui,Katsuhiko Mikoshiba,Hajime Hirase +6 more
TL;DR: It is demonstrated that astrocyte Ca2+ signaling provides a critical bridge between cholinergic activation, associated with attention and vigilance states, and somatosensory plasticity in mouse barrel cortex in vivo.
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Conditioned and unconditioned stimuli increase frontal cortical and hippocampal acetylcholine release: effects of novelty, habituation, and fear.
TL;DR: The data indicate that cortically and hippocampally projecting basal forebrain cholinergic neurons are activated by conditioned and unconditioned stimuli that produce arousal in rats (novelty or conditioned fear).
References
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Journal ArticleDOI
Magnesium gates glutamate-activated channels in mouse central neurones
TL;DR: The voltage dependence of the NMDA receptor-linked conductance appears to be a consequence of the voltage dependenceof the Mg2+ block and its interpretation does not require the implication of an intramembrane voltage-dependent ‘gate’.
Journal Article
Correlation of cholinergic abnormalities with senilee plaques and mental test scores in senile dementia
TL;DR: In this paper, the authors examined brain tissue from normal (control) patients and patients with depression and dementia for activities of various cholinergic components, and these related to the degree of senile plaque formation and extent of intellectual impairment.
Journal ArticleDOI
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
TL;DR: The results suggest a close relation between changes in the cholinergic system and Alzheimer's dementia, but the precise role of the system in this disease remains to be elucidated.
Journal ArticleDOI
Muscarinic suppression of a novel voltage-sensitive K + current in a vertebrate neurone
D.A. Brown,D.A. Brown,Paul Adams +2 more
TL;DR: Using voltage-clamped frog sympathetic neurones, this work has identified a distinctive voltage-sensitive K+ -current, separate from the delayed rectifier current, as the prime target for muscarinic agonists, and termed this current the M-current, IM.
Journal ArticleDOI
Somatosensory cortical map changes following digit amputation in adult monkeys
Michael M. Merzenich,R. J. Nelson,Michael P. Stryker,Max S. Cynader,Axel Schoppmann,John M. Zook +5 more
TL;DR: The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2–8 months after surgical amputation of digit 3, or of both digits 2 and 3.
Related Papers (5)
Cholinergic modulation of the functional organization of the cat visual cortex.
Adam M. Sillito,John A. Kemp +1 more