Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle
Romain Barrès,Jie Yan,Brendan Egan,Brendan Egan,Jonas T. Treebak,Morten Arendt Rasmussen,Tomas Fritz,Kenneth Caidahl,Anna Krook,Donal J. O’Gorman,Juleen R. Zierath,Juleen R. Zierath +11 more
TLDR
Results provide evidence that acute gene activation is associated with a dynamic change in DNA methylation in skeletal muscle and suggest that DNA hypomethylation is an early event in contraction-induced gene activation.About:
This article is published in Cell Metabolism.The article was published on 2012-03-07 and is currently open access. It has received 766 citations till now. The article focuses on the topics: DNA methylation & DNA hypomethylation.read more
Citations
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Journal ArticleDOI
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
TL;DR: The metabolic responses and molecular mechanisms that underpin the adaptatation of skeletal muscle to acute exercise and exercise training are reviewed.
Journal ArticleDOI
Integrative Biology of Exercise
John A. Hawley,John A. Hawley,Mark Hargreaves,Michael J. Joyner,Juleen R. Zierath,Juleen R. Zierath +5 more
TL;DR: The application of molecular techniques to exercise biology has provided greater understanding of the multiplicity and complexity of cellular networks involved in exercise responses, and recent discoveries offer perspectives on the mechanisms by which muscle "communicates" with other organs and mediates the beneficial effects of exercise on health and performance.
Journal ArticleDOI
Repurposing the CRISPR-Cas9 system for targeted DNA methylation
Aleksandar Vojta,Paula Dobrinić,Vanja Tadić,Luka Bočkor,Petra Korać,Boris Julg,Marija Klasić,Vlatka Zoldoš +7 more
TL;DR: A CRISPR-Cas9-based tool for specific DNA methylation consisting of deactivated Cas9 (dCas9) nuclease and catalytic domain of the DNA methyltransferase DNMT3A targeted by co–expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide is developed.
Journal ArticleDOI
Sex differences in human adipose tissues - the biology of pear shape
TL;DR: In this paper, a brief overview of the relationship of fat distribution to metabolic health in men and women, and then focus on mechanisms underlying sex differences in adipose tissue biology was provided.
Journal ArticleDOI
A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue
Tina Rönn,Petr Volkov,Cajsa Davegårdh,Tasnim Dayeh,Elin Hall,Anders H. Olsson,Emma Nilsson,Åsa Tornberg,Marloes Dekker Nitert,Karl-Fredrik Eriksson,Helena A. Jones,Leif Groop,Charlotte Ling +12 more
TL;DR: The genome-wide pattern of DNA methylation in human adipose tissue from 23 healthy men, with a previous low level of physical activity, before and after a six months exercise intervention is described, potentially affecting adipocyte metabolism.
References
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Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.
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Epigenetic Reprogramming in Mammalian Development
Wolf Reik,Wendy Dean,Jörn Walter +2 more
TL;DR: What is known about reprogramming in mammals and how it might relate to developmental potency and imprinting are discussed, including whether or not methylation is involved in the control of gene expression during normal development.
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Perceptions of epigenetics
TL;DR: During the past year, more than 2,500 articles, numerous scientific meetings and a new journal were devoted to the subject of epigenetics, portrayed by the popular press as a revolutionary new science — an antidote to the idea that the authors are hard-wired by their genes.
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Genomic DNA methylation: the mark and its mediators.
Robert J. Klose,Adrian Bird +1 more
TL;DR: The role of DNA methylation in controlling gene expression is illuminated and its links with histone modification and chromatin remodelling are strengthened, and the mechanisms by which it is targeted to specific regions of the genome are understood.
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Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar,Yehudit Bergman +1 more
TL;DR: Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.
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