Journal ArticleDOI
Adenosine decreases aspartate and glutamate release from rat hippocampal slices
TLDR
The hypothesis that adenosine modulates the electrophysiological responses to stimulation of stratum radiatum through a reduction of the release of the excitatory amino acids aspartate and glutamate is supported.About:
This article is published in European Journal of Pharmacology.The article was published on 1984-09-03. It has received 354 citations till now. The article focuses on the topics: Adenosine & Glutamic acid.read more
Citations
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Mechanisms of neuropathic pain
TL;DR: The majority of research into neuropathic pain mechanisms has concentrated on changes in the peripheral nerve or spinal cord after peripheral nerve injury and most available evidence relates to changes in these parts of the nervous system and the review will, therefore, focus on these aspects.
Journal ArticleDOI
Adenosine receptor activation and nociception
TL;DR: An understanding of the contribution of adenosine to pain processing is important for understanding how caffeine produces adjuvant analgesic properties in some situations, but might interfere with the optimal benefit to be derived from others.
Journal ArticleDOI
Extracellular Adenosine, Inosine, Hypoxanthine, and Xanthine in Relation to Tissue Nucleotides and Purines in Rat Striatum During Transient Ischemia
Henrik Hagberg,P. Andersson,J. Lacarewicz,Ingemar Jacobson,Steven P. Butcher,Michael A. Sandberg +5 more
TL;DR: The high EC levels of adenosine during ischemia may turn off spontaneous neuronal firing, counteract excitotoxicity, and inhibit ischemic calcium uptake, thereby exerting neuroprotective effects.
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Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus.
Ling-Gang Wu,Peter Saggau +1 more
TL;DR: Adenosine, through activation of presynaptic A1 receptors, inhibits the fEPSP primarily by reducing the Ca2+ transient, suggesting a tonic inhibition of the [Ca]t by endogenous adenosine in the hippocampal slice.
References
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Book
Statistical Principles in Experimental Design
TL;DR: In this article, the authors introduce the principles of estimation and inference: means and variance, means and variations, and means and variance of estimators and inferors, and the analysis of factorial experiments having repeated measures on the same element.
Journal ArticleDOI
Statistical Principles in Experimental Design
TL;DR: This chapter discusses design and analysis of single-Factor Experiments: Completely Randomized Design and Factorial Experiments in which Some of the Interactions are Confounded.
Journal ArticleDOI
The role of adenosine and its nucleotides in central synaptic transmission.
J.W. Phillis,P.H. Wu +1 more
Journal ArticleDOI
Unit analysis of hippocampal population spikes
TL;DR: It is concluded that over a wide range the height of the population spike is an increasing function of the number of discharging cells and can thus be used as a measure of the extent to which an afferent volley discharges a cell population.