Adenosine Triphosphate Conservation in Metabolic Regulation RAT LIVER CITRATE CLEAVAGE ENZYME
TLDR
The "energy charge" of the adenylate system, defined as (ATP + ½ ADP)/(AMP + ADP + ATP), is proposed as a fundamental metabolic control parameter.About:
This article is published in Journal of Biological Chemistry.The article was published on 1967-07-10 and is currently open access. It has received 801 citations till now. The article focuses on the topics: Energy charge & Adenosine triphosphate.read more
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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
Marc Foretz,Sophie Hébrard,Jocelyne Leclerc,Elham Zarrinpashneh,Maud Soty,Gilles Mithieux,Kei Sakamoto,Fabrizio Andreelli,Benoit Viollet +8 more
TL;DR: It is found that in mice lacking AMPK in the liver, blood glucose levels were comparable to those in wild-type mice, and the hypoglycemic effect of metformin was maintained, demonstrating that met formin inhibits hepatic gluconeogenesis in an LKB1- and AMPK-independent manner via a decrease in hepatic energy state.
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Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced
TL;DR: The results show that the transition of glutamate from neurotransmitter to neurotoxin is facilitated when cellular energy is limited in cultured cerebellar neurons, demonstrating that glucose metabolism, ATP production, and functioning Na+,K+-ATPases are necessary to generate a resting potential sufficient to maintain the voltage-dependent Mg2+ block of the NMDA receptor channel.
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Adenylate Energy Charge in Escherichia coli During Growth and Starvation
TL;DR: Tabulation of adenylate concentrations previously reported for various organisms and tissues supports the prediction, based on enzyme kinetic observations in vitro, that the energy charge is stabilized near 0.85 in intact metabolizing cells of a wide variety of types.
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Metabolic Control of Autophagy
TL;DR: The physiological regulation of autophagy by metabolic circuitries, as well as alterations of such control in disease are discussed.
References
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Journal ArticleDOI
The supply of precursors for the synthesis of fatty acids.
TL;DR: Citrate is rapidly incorporated into fatty acids in the mammary gland and the reaction that initiates this incorporation is catalyzed by the citrate cleavage enzyme.
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Adenylate as a metabolic regulator. effect on yeast phosphofructokinase kinetics.
TL;DR: The results presented here suggest that the ratio of the concentrations of AMP and ATP may regulate the activity of phosphofructokinase in yeast.
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Citrate and the conversion of carbohydrate into fat. the activities of citrate-cleavage enzyme and acetate thiokinase in livers of starved and re-fed rats.
Kornacker,Jm Lowenstein +1 more
TL;DR: The changes in activity of citrate-cleavage enzyme correlate with changes in the rate of fatty acid synthesis and provide evidence for the involvement of the citrate -cleavage reaction in fatty acid synthesisation.