The citrate cleavage enzyme. I. Distribution and purification.
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This article is published in Journal of Biological Chemistry.The article was published on 1959-10-01 and is currently open access. It has received 338 citations till now. The article focuses on the topics: ATP Citrate (pro-S)-Lyase & Citrate synthase.read more
Citations
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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
TL;DR: It is argued that altered metabolism has attained the status of a core hallmark of cancer.
Journal ArticleDOI
ATP citrate lyase inhibition can suppress tumor cell growth
Georgia Hatzivassiliou,Fangping Zhao,Daniel E. Bauer,Charalambos Andreadis,Shaw Antony N,Dashyant Dhanak,Sunil R. Hingorani,David A. Tuveson,Craig B. Thompson +8 more
TL;DR: ACL inhibition by RNAi or the chemical inhibitor SB-204990 limits in vitro proliferation and survival of tumor cells displaying aerobic glycolysis, and these treatments also reduce in vivo tumor growth and induce differentiation.
Journal ArticleDOI
Adenosine Triphosphate Conservation in Metabolic Regulation RAT LIVER CITRATE CLEAVAGE ENZYME
TL;DR: The "energy charge" of the adenylate system, defined as (ATP + ½ ADP)/(AMP + ADP + ATP), is proposed as a fundamental metabolic control parameter.
Journal ArticleDOI
Acetyl-CoA and the regulation of metabolism: mechanisms and consequences
Lei Shi,Benjamin P. Tu +1 more
TL;DR: Understanding the sources, fates, and consequences of acetyl-CoA as a carrier of two-carbon units has started to reveal its underappreciated but profound influence on the regulation of numerous life processes.
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Acetate dependence of tumors.
Sarah A. Comerford,Zhiguang Huang,Xinlin Du,Yun Wang,Ling Cai,Agnieszka K. Witkiewicz,Holly Walters,Mohammed N. Tantawy,Allie Fu,H. Charles Manning,Jay D. Horton,Robert E. Hammer,Steven L. McKnight,Benjamin P. Tu +13 more
TL;DR: It is shown that the nucleocytosolic acetyl-CoA synthetase enzyme, ACSS2, supplies a key source of acetyl -CoA for tumors by capturing acetate as a carbon source.
References
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Biosynthesis of glycogen from uridine diphosphate glucose.
TL;DR: Using UDPG labeled in the glucose moiety, it was found that the radioactivity was transferred to the glycogen from which it could be removed as maltose with β-amylase or as G-1-P with phosphorylase, suggesting that the glucose residue becomes linked α (1 → 4) to the polysaccharide.
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Enzymatic synthesis of citric acid: v. reaction of acetyl coenzyme a
Journal ArticleDOI
The role of co2 fixation in carbohydrate utilization and synthesis
TL;DR: The two reactions shown below are considered and their possible role in animal metabolism is considered and that of carbohydrate utilization and synthesis is considered.
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