Journal ArticleDOI
Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials
TLDR
It is suggested that aspirin might help in treatment of some cancers and provides proof of principle for pharmacological intervention specifically to prevent distant metastasis in patients who developed cancer during trials of daily aspirin versus control.About:Â
This article is published in The Lancet.The article was published on 2012-04-28. It has received 847 citations till now. The article focuses on the topics: Aspirin & Cancer.read more
Citations
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Inflammation and Cancer: Triggers, Mechanisms, and Consequences.
TL;DR: How tumor-promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis, or tissue repair is discussed and the distinctions between tissue-protective and pro-tumorigenic inflammation are illuminated.
Journal ArticleDOI
Cancer-related inflammation and treatment effectiveness
TL;DR: The complex interplay between local immune responses and systemic inflammation, and their influence on clinical outcomes, are examined, and potential anti-inflammatory interventions for patients with cancer are proposed.
Journal ArticleDOI
Inflammation and cancer: advances and new agents
TL;DR: It is asserted that inflammation and innate immunity are important targets in patients with cancer on the basis of extensive preclinical and epidemiological data and potential for novel cancer prevention and treatment strategies.
Journal ArticleDOI
Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus.
Louise Bowman,Marion Mafham,K Wallendszus,William M. Stevens,Georgina Buck,Jill Barton,Kevin T. Murphy,Theingi Aung,Richard Haynes,Jolyon Cox,Aleksandra Murawska,Allen Young,Michael Lay,Fang Chen,Emily L. Sammons,Emma Waters,Amanda I Adler,Jonathan Bodansky,Andrew Farmer,Roger McPherson,Andrew Neil,David Simpson,Richard Peto,Colin Baigent,Rory Collins,Sarah Parish,Jane Armitage +26 more
TL;DR: Aspirin use prevented serious vascular events in persons who had diabetes and no evident cardiovascular disease at trial entry, but it also caused major bleeding events.
Journal ArticleDOI
Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
Peter M. Rothwell,Jacqueline F. Price,F. Gerald R. Fowkes,Alberto Zanchetti,Maria Carla Roncaglioni,Gianni Tognoni,Robert J. Lee,Jill F. F. Belch,M Wilson,Ziyah Mehta,Tom W. Meade +10 more
TL;DR: The short-term reductions in cancer incidence and mortality and the decrease in risk of major extracranial bleeds with extended use, and their low case-fatality, add to the case for daily aspirin in prevention of cancer.
References
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Journal ArticleDOI
Estimates of the cancer incidence and mortality in Europe in 2006
TL;DR: The total number of new cases of cancer in Europe appears to have increased by 300,000 since 2004 and the ageing of the European population will cause these numbers to continue to increase even if age-specific rates remain constant.
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Global Patterns of Cancer Incidence and Mortality Rates and Trends
TL;DR: Changing global incidence and mortality patterns for select common cancers and the opportunities for cancer prevention in developing countries are described.
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Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues
TL;DR: Generic approaches to improve the balance between benefits and risks associated with the use of NSAIDs in chemoprevention are considered and strategies to overcome the various logistic and scientific barriers that impede clinical trials ofNSAIDs for cancer prevention are identified.
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Contribution of platelets to tumour metastasis.
TL;DR: Contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.
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Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials.
Peter M. Rothwell,F. Gerald R. Fowkes,Jill F. F. Belch,Hisao Ogawa,Charles P Warlow,Tom W. Meade +5 more
TL;DR: Benefit increased with duration of treatment and was consistent across the different study populations, having implications for guidelines on use of aspirin and for understanding of carcinogenesis and its susceptibility to drug intervention.