Age-related changes in cholesterol and bile acid metabolism in rats
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TLDR
Serum and liver lipid levels increased with age in both strains but the liver phospholipid level remained unchanged, and the proportion of serum alpha-lipoprotein increases and that of beta- and prebeta- lipoproteins slightly decreased.Citations
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Regulation of Intestinal Cholesterol Absorption
TL;DR: These findings indicate that cholesterol absorption is a multistep process that is regulated by multiple genes at the enterocyte level and that the efficiency of cholesterol absorption may be determined by the net effect between influx and efflux of intraluminal cholesterol molecules crossing the brush border membrane of the enterocytes.
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A novel use of chitosan as a hypocholesterolemic agent in rats
TL;DR: A proper supplementation of chitosan to the diet seemed to be effective in lowering plasma cholesterol, and relatively more cholesterol existed as high-density lipiproteins and less as very low- density lipoproteins.
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Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health.
TL;DR: The regulation of this gut-microbiota-liver axis in the context of bile acid metabolism is examined to indicate how this pathway represents an important target for the development of new nutraceutical (diet and/or probiotics) and targeted pharmaceutical interventions.
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Alternate pathways of bile acid synthesis in the cholesterol 7α-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding
TL;DR: It is concluded that in the mouse the rate of bile acid synthesis via alternative pathways is unresponsive to changes in the enterohepatic flux of cholesterol and bile acids, and that factors governing gender-related differences in bile Acid synthesis, pool size, and pool composition play an important role in determining the impact of CYP7A1 deficiency on cholesterol homeostasis in this species.
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Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS
TL;DR: The method for analyzing BA composition in various tissues and intestinal contents using ultra performance liquid chromatography/electrospray ionization mass spectrometry (UPLC/ESI-MS) established will be useful for investigating the roles of BA metabolism under physiological and pathological conditions.
References
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A simple method for the isolation and purification of total lipides from animal tissues.
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
TL;DR: The relatively low density of the lipoproteins was utilized by Lindgren, Elliott, and Gofman to separate them from the other serum proteins by ultracentrifugal flotation, and quantitation was subsequently performed by refractometric methods in the analytical ultracentRifuge.
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A modification of the colorimetric phosphorus determination for use with the photoelectric colorimeter.
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A colorimetric method for estimating serum triglycerides
TL;DR: The glycerol released by saponification of the serum glycerides is oxidized to formaldehyde which reacts with acetylacetone to form a yellow dihydrolutidine derivative absorbing at 405 mμ, correlates well with those given by the ZilversmitVan Handel method.
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Quantitative isolation and gas–liquid chromatographic analysis of total fecal bile acids
TL;DR: This experiment indicated the stability of bile acid structure during intestinal transit and provided additional evidence for the completeness of the described method of determining fecal bile acids.