Journal ArticleDOI
Agonist-like, replacement pharmacotherapy for stimulant abuse and dependence
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TLDR
The authors consider agonist and antagonist pharmacotherapy strategies, preclinical research, including methodological approaches, opioid and nicotine replacement, and agonists for stimulant dependence, and application of agonist-like/replacement strategies, including clinical requirements and risks.About:
This article is published in Addictive Behaviors.The article was published on 2004-09-01. It has received 259 citations till now. The article focuses on the topics: Nicotine replacement & Amphetamine dependence.read more
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The need for speed: an update on methamphetamine addiction.
Alasdair M. Barr,William J. Panenka,G. William MacEwan,Allen E. Thornton,Donna J. Lang,William G. Honer,Tania Lecomte +6 more
TL;DR: This work provides a comprehensive description of the factors relating to MA use and the major health-related consequences, with an emphasis on MA-induced psychosis, and hopes that increased knowledge of MA abuse will provide the basis for future treatment strategies.
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Controversies in translational research: drug self-administration
Margaret Haney,Roger D. Spealman +1 more
TL;DR: The self-administration model has reliably identified medications to treatment opioid dependence, and the recent data with modafinil suggest that the human laboratory model also identifies medications to treat cocaine dependence.
Journal ArticleDOI
SLC6 transporters: structure, function, regulation, disease association and therapeutics.
TL;DR: The SLC6 family of secondary active transporters are integral membrane solute carrier proteins characterized by the Na(+)-dependent translocation of small amino acid or amino acid-like substrates that are associated with a number of human diseases and disorders making this family a critical target for therapeutic development.
Journal ArticleDOI
Drug policy and the public good: evidence for effective interventions
John Strang,Thomas F. Babor,Jonathan P. Caulkins,Jonathan P. Caulkins,Benedikt Fischer,Benedikt Fischer,David R. Foxcroft,Keith Humphreys +7 more
TL;DR: relevant evidence is reviewed and the likely effects of fuller implementation of existing interventions are outlined, which are capable of making drugs less available, reducing violence in drug markets, lessening misuse of legal pharmaceuticals, and reducing drug use and its consequences in established drug users.
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Characteristics of Adolescents and Young Adults with ADHD Who Divert or Misuse Their Prescribed Medications.
TL;DR: The data indicate that the majority of ADHD individuals, particularly those without conduct or substance use disorders, use their medications appropriately, and the need to monitor medication use in ADHD individuals with conduct and/or Substance use disorders is highlighted.
References
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Journal ArticleDOI
The self-medication hypothesis of addictive disorders: Focus on heroin and cocaine dependence.
TL;DR: Clinical observations and psychiatric diagnostic findings of drug-dependent individuals suggest that they are predisposed to addiction because they suffer with painful affect states and related psychiatric disorders.
Journal ArticleDOI
Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence
TL;DR: Buprenorphine maintenance compared to placebo and to methadone maintenance in the management of opioid dependence, including its ability to retain people in treatment, suppress illicit drug use, reduce criminal activity, and mortality is evaluated.
Book
The Effectiveness of Methadone Maintenance Treatment: Patients, Programs, Services, and Outcome
John C. Ball,Alan Ross +1 more
Journal ArticleDOI
The dopamine hypothesis of the reinforcing properties of cocaine
TL;DR: A variety of evidence suggests a 'dopamine hypothesis' for the reinforcing properties of cocaine that proposes that cocaine binds at the dopamine transporter and mainly inhibits neurotransmitter re-uptake; the resulting potentiation of dopaminergic neurotransmission in mesolimbocortical pathways ultimately causes reinforcement.