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Alcohol Consumption and Risk of Ischemic Stroke: The Framingham Study

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TLDR
The data showed no significant association between total alcohol and IS overall but showed a protective effect of alcohol among subjects aged 60 to 69 years, when stratified by age.
Abstract
Background and Purpose— Stroke is a major cause of death in the United States. The association between alcohol consumption and ischemic stroke (IS) remains controversial. Methods— We used data collected on participants in the Framingham Study to assess the association between total alcohol intake and type of alcoholic beverage and development of IS, overall and according to age. Results— A total of 196 men and 245 women developed IS during three 10-year follow-up periods. In the categories of never drinkers, drinkers of 0.1 to 11, 12 to 23, and ≥24 g/d of ethanol (a “typical drink” is ≈12 g of ethanol), and former drinkers of 0.1 to 11 and ≥12 g/d, crude incidence rates of IS were 6.5, 5.9, 4.9, 5.0, 6.7, and 17.8 cases per 1000 person-years, respectively, for men and 5.9, 4.1, 4.1, 4.3, 8.3, and 7.1, respectively, for women. Overall, compared with never drinkers in a multivariate Cox regression, current alcohol consumption was not related significantly to IS in either sex. Former drinking of ≥12 g/d of a...

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Citations
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Journal ArticleDOI

Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association

TL;DR: In this paper, the authors provided evidence-based recommendations for the prevention of future stroke among survivors of ischemic stroke or transient ischemi-chemic attack, including the control of risk factors, intervention for vascular obstruction, antithrombotic therapy for cardioembolism, and antiplatelet therapy for noncardioembolic stroke.
Journal ArticleDOI

Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic Attack : A statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke : Co-sponsored by the Council on Cardiovascular Radiology and Intervention : The American Academy of Neurology affirms the value of this guideline

TL;DR: In this paper, the authors provide comprehensive and timely evidence-based recommendations on the prevention of ischemic stroke among survivors of stroke or transient ischemi stroke, including the control of risk factors, interventional approaches for atherosclerotic disease, antithrombotic treatments for cardioembolism, and the use of antiplatelet agents for noncardioembolic stroke.
Journal ArticleDOI

Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack

TL;DR: Evidence-based recommendations are included for the control of risk factors, interventional approaches for atherosclerotic disease, antithrombotic treatments for cardioembolism, and the use of antiplatelet agents for noncardioembolic stroke.
Journal ArticleDOI

Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis

TL;DR: Light to moderate alcohol consumption is associated with a reduced risk of multiple cardiovascular outcomes, and the lowest risk of coronary heart disease mortality occurred with 1–2 drinks a day, but for stroke mortality it occurred with ≤1 drink per day.
References
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Journal ArticleDOI

Wine, alcohol, platelets, and the French paradox for coronary heart disease

TL;DR: Data from Caerphilly, Wales, show that platelet aggregation, which is related to CHD, is inhibited significantly by alcohol at levels of intake associated with reduced risk of CHD.
Journal ArticleDOI

Probability of stroke: a risk profile from the Framingham Study.

TL;DR: A health risk appraisal function has been developed for the prediction of stroke using the Framingham Study cohort and may help to identify persons at substantially increased stroke risk resulting from borderline levels of multiple risk factors such as those with mild or borderline hypertension and facilitate multifactorial risk factor modification.
Journal ArticleDOI

Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine

TL;DR: In in-vitro studies with phenolic substances in red wine and normal human low-density lipoprotein (LDL) the authors found that red wine inhibits the copper-catalysed oxidation of LDL.
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