Alirocumab as Add-On to Atorvastatin Versus Other Lipid Treatment Strategies: ODYSSEY OPTIONS I Randomized Trial
Harold Bays,Daniel Gaudet,Robert M. Weiss,Juan Lima Ruiz,Gerald F. Watts,Ioanna Gouni-Berthold,Jennifer G. Robinson,Jian Zhao,Corinne Hanotin,Stephen Donahue +9 more
TLDR
Adding alirocumab to atorvastatin provided significantly greater LDL-C reductions vs adding ezetimibe, doubling atorVastatin dose, or switching to rosuvastATin and enabled greater cholesterol-lowering goal achievement.Abstract:
Context: Despite current standard of care, many patients at high risk of cardiovascular disease (CVD) still have elevated low-density lipoprotein cholesterol (LDL-C) levels. Alirocumab is a fully human monoclonal antibody inhibitor of proprotein convertase subtilisin/kexin type 9. Objective: The objective of the study was to compare the LDL-C-lowering efficacy of adding alirocumab vs other common lipid-lowering strategies. Design, Patients, and Interventions: Patients (n = 355) with very high CVD risk and LDL-C levels of 70 mg/dL or greater or high CVD risk and LDL-C of 100 mg/dL or greater on baseline atorvastatin 20 or 40 mg were randomized to one of the following: 1) add-on alirocumab 75 mg every 2 weeks (Q2W) sc; 2) add-on ezetimibe 10 mg/d; 3) double atorvastatin dose; or 4) for atorvastatin 40 mg regimen only, switch to rosuvastatin 40 mg. For patients not achieving protocol-defined LDL-C goals, the alirocumab dose was increased (blinded) at week 12 to 150 mg Q2W. Main Outcome Measure: The primary e...read more
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Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus – Mechanisms, Management, and Clinical Considerations
TL;DR: This review considers the mechanisms, history, controversies, new pharmacological agents, and recent evidence for current guidelines for cardiovascular management in the patient with diabetes mellitus to support evidence-based care outside of the acute care setting.
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Consensus statement by the american association of clinical endocrinologists and american college of endocrinology on the comprehensive type 2 diabetes management algorithm--2016 executive summary.
Alan J. Garber,Martin J. Abrahamson,Joshua I. Barzilay,Lawrence Blonde,Zachary T. Bloomgarden,Michael A. Bush,Samuel Dagogo-Jack,Ralph A. DeFronzo,Daniel Einhorn,Vivian Fonseca,Jeffrey R. Garber,W. Timothy Garvey,George Grunberger,Yehuda Handelsman,Robert R. Henry,Irl B. Hirsch,Paul S. Jellinger,Janet B. McGill,Jeffrey I. Mechanick,Paul D. Rosenblit,Guillermo E. Umpierrez +20 more
TL;DR: This chapter discusses the development and use of eicosapentaenoic acid as a treatment for diabetic ketoacidosis and its applications in conventional and regenerative medicine.
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Consensus Statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the Comprehensive Type 2 Diabetes Management Algorithm – 2018 Executive Summary
Alan J. Garber,Martin J. Abrahamson,Joshua I. Barzilay,Joshua I. Barzilay,Lawrence Blonde,Zachary T. Bloomgarden,Michael A. Bush,Michael A. Bush,Samuel Dagogo-Jack,Ralph A. DeFronzo,Daniel Einhorn,Vivian Fonseca,Jeffrey R. Garber,W. Timothy Garvey,George Grunberger,Yehuda Handelsman,Irl B. Hirsch,Paul S. Jellinger,Janet B. McGill,Jeffrey I. Mechanick,Jeffrey I. Mechanick,Jeffrey I. Mechanick,Paul D. Rosenblit,Guillermo E. Umpierrez,Guillermo E. Umpierrez +24 more
TL;DR: The objective of the trial was to establish whether or not the initial treatment strategy improved the patient’s quality of life and/or lowered the risk of adverse events.
Journal ArticleDOI
Consensus statement by the american association of clinical endocrinologists and american college of endocrinology on the comprehensive type 2 diabetes management algorithm - 2017 executive summary
Alan J. Garber,Martin J. Abrahamson,Joshua I. Barzilay,Lawrence Blonde,Zachary T. Bloomgarden,Michael A. Bush,Samuel Dagogo-Jack,Ralph A. DeFronzo,Daniel Einhorn,Vivian Fonseca,Jeffrey R. Garber,W. Timothy Garvey,George Grunberger,Yehuda Handelsman,Irl B. Hirsch,Paul S. Jellinger,Janet B. McGill,Jeffrey I. Mechanick,Paul D. Rosenblit,Guillermo E. Umpierrez +19 more
TL;DR: This monograph describes the development and use of various strategies to reduce the risk of heart attack and stroke in patients with type 2 diabetes through a variety of treatments, including vaccination, diet and lifestyle modifications.
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Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial
Patrick M. Moriarty,Paul D. Thompson,Christopher P. Cannon,John R. Guyton,Jean Bergeron,Franklin J. Zieve,Eric Bruckert,Terry A. Jacobson,Stephen L. Kopecky,Marie T. Baccara-Dinet,Yunling Du,Robert Pordy,Daniel A. Gipe +12 more
TL;DR: Alirocumab produced greater LDL-C reductions than ezetimibe in statin-intolerant patients, with fewer skeletal-muscle adverse events vs atorvastatin.
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