Allergy and risk of hematologic malignancies: associations and mechanisms.
TLDR
The aim of this review is to report the preclinical and clinical data, which support a correlation between allergy and hematologic neoplasms, and to suggest that immune system modulation could represent a powerful tool in the prevention and treatment of hematological malignancies.About:
This article is published in Leukemia Research.The article was published on 2014-10-01 and is currently open access. It has received 17 citations till now.read more
Citations
More filters
Journal ArticleDOI
Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry
P.C. Mayor,Kevin H. Eng,Kelly L. Singel,Scott I. Abrams,Kunle Odunsi,Kirsten B. Moysich,Ramsay Fuleihan,Elizabeth Garabedian,Patricia L. Lugar,Hans D. Ochs,Francisco A. Bonilla,Rebecca H. Buckley,Kathleen E. Sullivan,Zuhair K. Ballas,Charlotte Cunningham-Rundles,Brahm H. Segal,Brahm H. Segal +16 more
TL;DR: Data point to a restricted role of the immune system in protecting from specific cancers, as an excess of lymphoma in specific PIDD populations principally drove this increased incidence, while no increased risk of the most common solid tumor malignancies was observed.
Journal ArticleDOI
Lymphoproliferative disease and cancer among patients with common variable immunodeficiency.
TL;DR: The latest insights into the links between common variable immunodeficiency (CVI) and malignancies are discussed, including genetics, immune dysregulation, radiosensitivity and chronic infections such as Helicobacter pylori, EBV, human herpes virus type 8 and cytomegalovirus.
Journal ArticleDOI
An Updated Review on Cancer Risk Associated with Incretin Mimetics and Enhancers
TL;DR: Based on current evidence, continuous monitoring of the cancer issues related to incretin-based therapies is required, even though the benefits may outweigh the potential cancer risk in the general patients with type 2 diabetes mellitus.
Journal ArticleDOI
Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma: A United Kingdom nationwide case-control study.
Meena Rafiq,Andrew Hayward,Charlotte Warren-Gash,Spiros Denaxas,Arturo Gonzalez-Izquierdo,Georgios Lyratzopoulos,Sara L Thomas +6 more
TL;DR: Findings add to the growing evidence that immune system malfunction after allergic disease or immunosuppression is central to HL development.
Journal ArticleDOI
Vaccination strategies in lymphoproliferative disorders: Failures and successes
Alessandro Allegra,Sabina Russo,Demetrio Gerace,Luana Calabrò,Valerio Maisano,Vanessa Innao,Caterina Musolino +6 more
TL;DR: The addition of immunotherapy to old and new chemotherapy regimens has improved both response rates and disease-free survival, leading in many cases to an extended overall survival.
References
More filters
Journal ArticleDOI
Hay fever, hygiene, and household size.
TL;DR: A possible explanation forHay fever trends over time is suggested, as well as a recent increase in the prevalence of asthma2 and childhood eczema.
Journal Article
Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile
Susan L. Prescott,Claudia Macaubas,Barbara J. Holt,T.B. Smallacombe,Richard Loh,Peter D. Sly,Patrick G. Holt +6 more
TL;DR: These findings imply that the key etiologic factor in atopic disease may not be the initial acquisition of allergen-specific Th2-skewed immunity per se, but instead may be the efficiency of immune deviation mechanisms, which in normal (nonatopic) individuals redirect these fetal immune responses toward the Th1 cytokine phenotype.
Journal ArticleDOI
Clonal Diseases of Large Granular Lymphocytes
TL;DR: Three distinct clinical syndromes occur in patients with increased numbers of circulating LGL, and X-linked gene analyses have supported a polyclonal LGL lymphocytosis in this syndrome.
Journal ArticleDOI
Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia
Hanna Koskela,Samuli Eldfors,Pekka Ellonen,Arjan J. van Adrichem,Heikki Kuusanmäki,Emma I. Andersson,Sonja Lagström,Michael J. Clemente,Thomas L. Olson,Sari E. Jalkanen,Muntasir Mamun Majumder,Henrikki Almusa,Henrik Edgren,Maija Lepistö,Pirkko Mattila,Kathryn M Guinta,Pirjo Koistinen,Taru Kuittinen,Kati Penttinen,Alun Parsons,Jonathan Knowles,Janna Saarela,Krister Wennerberg,Olli Kallioniemi,Kimmo Porkka,Thomas P. Loughran,Caroline A. Heckman,Jaroslaw P. Maciejewski,Satu Mustjoki +28 more
TL;DR: The SH2 dimerization and activation domain of STAT3 is frequently mutated in patients with large granular lymphocytic leukemia; these findings suggest that aberrant STAT3 signaling underlies the pathogenesis of this disease.
Journal ArticleDOI
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
Pearlie K. Epling-Burnette,Jin Hong Liu,Robyn Catlett-Falcone,James Turkson,Marc M. Oshiro,Ravi Kothapalli,Yongxiang Li,Ju-Ming Wang,Hsin-Fang Yang-Yen,James G. Karras,Richard Jove,Thomas P. Loughran +11 more
TL;DR: It is concluded that STAT3 activation contributed to accumulation of the leukemic LGL clones by inducing apoptosis with the JAK-selective tyrosine kinase inhibitor AG-490 and using an antisense oligonucleotide approach to diminish STAT3 expression.