Recent insights into the role of the microbiome in malignant and benign hematologic diseases.
TLDR
In this article, a review of studies concerning the impact of microbiome alteration on malignant and benign hematologic disorders beyond stem cell transplant (HSCT) is presented. But most of these studies were focused on hematopoietic stem cell transplants.Abstract:
Growing evidence suggests the impact of microbiome alteration, named dysbiosis, on the development of neoplasms, infections, inflammatory diseases, and immuno-mediated disorders. Regarding hematologic diseases, most data regard hematopoietic stem cell transplant (HSCT). In this review, we systematically evaluate the studies concerning microbiome in malignant and benign hematologic disorders beyond HSCT. A permissive microbiota is associated to the development of hematologic malignancies (including acute leukemia, lymphoma, and multiple myeloma), as well as of iron deficiency anemia, autoimmune cytopenias, and aplastic anemia. This happens through various mechanisms; chronic inflammatory triggering, epithelial barrier alteration, antigen dissequestration, and molecular mimicry. Hematologic therapies (chemo and immunosuppression) may induce/worsen dysbiosis and favour disease progression and infectious complications. Antibiotics may also induce dysbiosis with possible long-term consequences. Finally, novel target therapies are likely to alter microbiome, inducing gut inflammation (i.e. small molecules such as tyrosine-kinase-inhibitors) or enhancing host's immune system (as observed with CAR-T cells and checkpoint inhibitors).read more
Citations
More filters
Journal ArticleDOI
Autoimmune Complications in Hematologic Neoplasms.
TL;DR: In this paper, the authors analyzed the available literature of the last 30 years regarding the occurrence of AICy/AID in different onco-hematologic conditions, including chronic lymphocytic leukemia (CLL), lymphomas, multiple myeloma, myelodysplastic syndromes (MDS), chronic myelomonocytic leucocyte leukemia (CMML), myeloproliferative neoplasms, and acute leukemias.
Journal ArticleDOI
Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms.
Zhuangzhuang Shi,Mingzhi Zhang +1 more
TL;DR: The disease burden of lymphoid neoplasms has been rising globally over the last decade as discussed by the authors, and the number of malignancies with a predilection for immunocompromised individuals has been increasing rapidly.
Journal ArticleDOI
The Microbiome in Childhood Acute Lymphoblastic Leukemia.
TL;DR: A review of the latest studies in pediatric ALL patients can be found in this article, where the impact of microbiome alterations on the etiology of acute lymphoblastic leukemia in children is not fully understood, but has been the focus of much research in recent years.
Journal ArticleDOI
Autoimmune hemolytic anemia: causes and consequences
TL;DR: In this article , the authors classified AIHA into warm and cold forms, and in primary versus secondary depending on the presence of associated conditions, including genetic (association with congenital conditions and certain mutations), environmental (drugs, infections, including SARS-CoV-2, pollution, etc.).
Journal ArticleDOI
The importance of microbiota in hematology.
TL;DR: In this paper, the structure and function of the microbiome in patients with benign and malignant hematological diseases was investigated, and the use of probiotics and dietary prebiotic substances targeting microbiota modification aiming to improve hematology disease outcomes should be investigated in future studies.
References
More filters
Journal ArticleDOI
A human gut microbial gene catalogue established by metagenomic sequencing
Junjie Qin,Ruiqiang Li,Jeroen Raes,Manimozhiyan Arumugam,Kristoffer Sølvsten Burgdorf,Chaysavanh Manichanh,Trine Nielsen,Nicolas Pons,Florence Levenez,Takuji Yamada,Daniel R. Mende,Junhua Li,Junming Xu,Shaochuan Li,Dongfang Li,Jianjun Cao,Bo Wang,Huiqing Liang,Huisong Zheng,Yinlong Xie,Julien Tap,Patricia Lepage,Marcelo Bertalan,Jean-Michel Batto,Torben Hansen,Denis Le Paslier,Allan Linneberg,H. Bjørn Nielsen,Eric Pelletier,Pierre Renault,Thomas Sicheritz-Pontén,Keith Turner,Hongmei Zhu,Chang Yu,Shengting Li,Min Jian,Yan Zhou,Yingrui Li,Xiuqing Zhang,Songgang Li,Nan Qin,Huanming Yang,Jian Wang,Søren Brunak,Joël Doré,Francisco Guarner,Karsten Kristiansen,Oluf Pedersen,Julian Parkhill,Jean Weissenbach,Peer Bork,S. Dusko Ehrlich,Jun Wang +52 more
TL;DR: The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species.
Journal ArticleDOI
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
Yuan Chang,Ethel Cesarman,Melissa S. Pessin,Frank Lee,Janice Culpepper,Daniel M. Knowles,Patrick S. Moore +6 more
TL;DR: unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus.
Journal ArticleDOI
The human microbiome project.
Peter J. Turnbaugh,Ruth E. Ley,Micah Hamady,Claire M. Fraser-Liggett,Rob Knight,Jeffrey I. Gordon +5 more
TL;DR: A strategy to understand the microbial components of the human genetic and metabolic landscape and how they contribute to normal physiology and predisposition to disease.
Journal ArticleDOI
Metagenomic Analysis of the Human Distal Gut Microbiome
Steven R. Gill,Mihai Pop,Robert T. DeBoy,Paul B. Eckburg,Paul B. Eckburg,Peter J. Turnbaugh,Buck S. Samuel,Jeffrey I. Gordon,David A. Relman,David A. Relman,Claire M. Fraser-Liggett,Karen E. Nelson +11 more
TL;DR: Using metabolic function analyses of identified genes, the human genome is compared with the average content of previously sequenced microbial genomes and humans are superorganisms whose metabolism represents an amalgamation of microbial and human attributes.
Journal ArticleDOI
Diversity, stability and resilience of the human gut microbiota
Catherine A. Lozupone,Jesse Stombaugh,Jeffrey I. Gordon,Janet K. Jansson,Rob Knight,Rob Knight +5 more
TL;DR: Viewing the microbiota from an ecological perspective could provide insight into how to promote health by targeting this microbial community in clinical treatments.