Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure.
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TLDR
It is proposed that selectively activating α1-adrenergic receptors in the heart might represent a novel and effective way to treat heart failure.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2011-10-01 and is currently open access. It has received 104 citations till now. The article focuses on the topics: Heart failure & Receptor.read more
Citations
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Journal ArticleDOI
Cardiovascular remodelling in coronary artery disease and heart failure
Gerd Heusch,Peter Libby,Bernard J. Gersh,Derek M. Yellon,Michael Böhm,Gary D. Lopaschuk,Lionel H. Opie +6 more
TL;DR: The remodelling processes in atherosclerosis, vascular and myocardial ischaemia-reperfusion injury, and heart failure are characterised, and potential avenues for innovative therapeutic approaches are drawn attention, including conditioning and metabolic strategies.
Journal ArticleDOI
The Autonomic Nervous System and Heart Failure
Viorel G. Florea,Jay N. Cohn +1 more
TL;DR: The data supporting a contributory role of the autonomic functional alterations on the course of HF is analyzed, the techniques used to assess autonomic nervous system activity are reviewed, the evidence for clinical effectiveness of pharmacological and device interventions, and the potential future role of autonomics nervous system modifiers in the management of this syndrome are analyzed.
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Cardiac Alpha1-Adrenergic Receptors: Novel Aspects of Expression, Signaling Mechanisms, Physiologic Function, and Clinical Importance
TL;DR: Interestingly, at the molecular level, alpha1-ARs localize to and signal at the nucleus in cardiac myocytes, and, unlike most GPCRs, activate “inside-out” signaling to cause cardioprotection.
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Agonist-Induced Hypertrophy and Diastolic Dysfunction Are Associated With Selective Reduction in Glucose Oxidation A Metabolic Contribution to Heart Failure With Normal Ejection Fraction
Jun Mori,Ratnadeep Basu,Brent A. McLean,Subhash K. Das,Liyan Zhang,Vaibhav B. Patel,Cory S. Wagg,Zamaneh Kassiri,Gary D. Lopaschuk,Gavin Y. Oudit +9 more
TL;DR: In this paper, the qualitative and quantitative effects of angiotensin II (Ang II) and the α-adrenergic agonist, phenylephrine (PE), on cardiac energy metabolism in experimental models of hypertrophy and diastolic dysfunction and the role of the Ang II type 1 receptor were assessed.
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PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating.
Mark A. Zaydman,Jianmin Cui +1 more
TL;DR: It is suggested that lipid-mediated coupling of functional domains is a common mechanism among KCNQ channels that may be applicable to other Kv channels and membrane proteins.
References
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2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the International Society for Heart and Lung Transplantation
Sharon A. Hunt,William T. Abraham,Marshall H. Chin,Arthur M. Feldman,Gary S. Francis,Theodore G. Ganiats,Mariell Jessup,Marvin A. Konstam,Donna Mancini,Keith Michl,John A. Oates,Peter S. Rahko,Marc A. Silver,Lynne W. Stevenson,Clyde W. Yancy +14 more
TL;DR: Theodore G. Feldman, MD, PhD, FACC, FAHA, Chair as mentioned in this paper, Chair, Chair of FAHA 2015, 2016, 2017, 2018, 2019, 2019
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Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure
Jay N. Cohn,T. B. Levine,Maria Teresa Olivari,Garberg,Lura D,Gary S. Francis,Ada B. Simon,Tom S. Rector +7 more
TL;DR: Measurements of Hemodynamics, plasma norepinephrine, and plasma renin activity in patients with moderate to severe congestive heart failure suggest that a single resting venous blood sample showing the plasma norenphrine concentration provides a better guide to prognosis than other commonly measured indexes of cardiac performance.
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Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.
Michael R. Bristow,Ginsburg R,Minobe W,Cubicciotti Rs,Sageman Ws,Keith G. Lurie,Billingham Me,Harrison Dc,Stinson Eb +8 more
TL;DR: It is concluded that in failing human hearts a decrease in beta-receptor density leads to subsensitivity of the beta-adrenergic pathway and decreased beta-agonist-stimulated muscle contraction.
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Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial
Philip A. Poole-Wilson,Karl Swedberg,John G.F. Cleland,Andrea Di Lenarda,Peter Hanrath,Michel Komajda,Jacobus Lubsen,Beatrix Lutiger,Marco Metra,Willem J. Remme,Christian Torp-Pedersen,Armin Scherhag,Allan M. Skene +12 more
TL;DR: The results suggest that carvedilol extends survival compared with metoprolol.
Journal Article
Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)
TL;DR: The data indicate that compared with doxazosin, chlorthalidone reduces the risk of combined CVD events, particularly CHD death/nonfatal MI, in high-risk hypertensive patients.