Journal ArticleDOI
Alterations in type I and type II protein kinases in the thyroid and adenohypophysis in response to a dietary goitrogen
TLDR
Data implicate both activation of the enzymes as well as increased amounts of types I and II protein kinase activity in the thyroid in response to goitrogen-induced hypertrophy and hyperplasia.About:
This article is published in General and Comparative Endocrinology.The article was published on 1980-04-01. It has received 13 citations till now. The article focuses on the topics: Protein kinase A & Goitrogen.read more
Citations
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Journal ArticleDOI
Acrylamide: Review of Toxicity Data and Dose-Response Analyses for Cancer and Noncancer Effects
Annette M. Shipp,Greg Lawrence,R Gentry,Tracy B. McDonald,H Bartow,J Bounds,N Macdonald,Harvey J. Clewell,Bruce C. Allen,C. Van Landingham +9 more
TL;DR: The purpose of this investigation was to review the toxicity data, identify any new relevant data, and select those data to be used in dose-response modeling, and proposed revised cancer and noncancer toxicity values were estimated using the newest U.S. EPA guidelines for cancer risk assessment and non cancer hazard assessment.
Journal Article
Prolonged ornithine decarboxylase induction in regenerating carcinogen-treated liver.
TL;DR: Analysis of biochemical parameters in a rapid multistep hepatocarcinogenesis system found a marked and prolonged increase in the cAPK ratio followed by a similar pattern of ODC induction after a single carcinogenic dose of diethylnitrosamine and again in response to partial hepatectomy.
Journal ArticleDOI
Pairs of cyclic AMP analogs, that are specifically synergistic for type I and type II cAMP-dependent protein kinases, mimic thyrotropin effects on the function, differentiation expression and mitogenesis of dog thyroid cells.
Jacqueline Van Sande,Anne Lefort,Stephen Beebe,Pierre P. Roger,Jason Perret,Jackie D Corbin,Jacques Emile Dumont +6 more
TL;DR: Both cAMP-dependent protein kinase isozymes can mediate the action of cAMP on function, differentiation expression and cell proliferation in dog thyroid cells.
Journal ArticleDOI
Antiproliferative Effects of Retinoids Related to the Cell Cycle-Specific Inhibition of Ornithine Decarboxylase
TL;DR: The studies of the effects of retinoids to inhibit Chinese hamster ovary (CHO) cell growth indicate that the cells are blocked in G1 of cell cycle, and that there is a concentration-dependent inhibition of ODC induction.
Journal ArticleDOI
Decrease in cAMP-dependent protein kinase activity in suspension cultures of porcine thyroid cells exposed to TSH or forskolin.
TL;DR: PAGE patterns showed that the decrease in endogenous phosphorylation in TSH- and Fk-treated cells was due to decreased labelling of PKa-specific substrates, which could have an influence on the expression of thyroid cell differentiation.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Book
Advances in cyclic nucleotide research.
TL;DR: Books and internet are the recommended media to help you improving your quality and performance.
Journal ArticleDOI
Cyclic nucleotide-dependent protein kinases, iv. widespread occurrence of adenosine 3′,5′-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom
J.F. Kuo,Paul Greengard +1 more
TL;DR: The data support a unifying theory for the mechanism of action of adenosine 3',5'-monophosphate, namely that its many and diverse effects are mediated through activation of tissue-specific protein kinases.
Book ChapterDOI
The action of thyrotropin on thyroid metabolism.
TL;DR: This chapter discusses the action of thyrotropin on thyroid metabolism, which involves the formation of thyroid hormones from iodide and tyrosines and the secretion of these hormones, and induces, after a delay, the growth of thyroid tissue.