Journal ArticleDOI
Alterations of regional spontaneous neuronal activity and corresponding brain circuit changes during resting state in migraine without aura.
Ting Xue,Kai Yuan,Ping Cheng,Ling Zhao,Limei Zhao,Dahua Yu,Dahua Yu,Tao Dong,Karen M. von Deneen,Qiyong Gong,Wei Qin,Jie Tian,Jie Tian +12 more
TLDR
Baseline cerebral alterations were investigated using amplitude of low‐frequency fluctuation and region of interest (ROI)‐based functional connectivity (FC) analyses, which could lead to a better understanding of intrinsic functional architecture of baseline brain activity in MwoA.Abstract:
Although previous resting-state studies have reported abnormal functional cerebral changes in patients with migraine without aura (MwoA), few have focused on alterations in both regional spontaneous neuronal activity and corresponding brain circuits in MwoA patients during rest. Eighteen MwoA patients and 18 age- and gender-matched healthy controls (HC) were recruited in the current study. Baseline cerebral alterations were investigated using amplitude of low-frequency fluctuation (ALFF) and region of interest (ROI)-based functional connectivity (FC) analyses. Compared with HC, MwoA patients showed decreased ALFF values in the left rostral anterior cingulate cortex (rACC) and bilateral prefrontal cortex (PFC) as well as increased ALFF values in the right thalamus. FC analysis also revealed abnormal FCs associated with these ROIs. In addition, ALFF values of the left rACC correlated with duration of disease in MwoA. Our findings could lead to a better understanding of intrinsic functional architecture of baseline brain activity in MwoA, providing both regional and brain circuit spontaneous neuronal activity properties. Copyright (c) 2013 John Wiley & Sons, Ltd.read more
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Journal ArticleDOI
Migraine and its psychiatric comorbidities
Mia T. Minen,Olivia Begasse de Dhaem,Ashley M. Kroon Van Diest,Scott W. Powers,Todd J. Schwedt,Richard B. Lipton,David Silbersweig +6 more
TL;DR: An overview of the link between migraine and several comorbid psychiatric disorders, including depression, anxiety and post-traumatic stress disorder is provided and data on psychiatric risk factors for migraine chronification is presented.
Journal ArticleDOI
Functional MRI of migraine
TL;DR: Identification of the mechanisms that lead to migraine sensory hypersensitivities and that trigger migraine attacks in response to sensory stimuli might help to better understand neural dysfunction in migraine and provide new targets for migraine prevention, and could provide fMRI biomarkers that indicate early responses to preventive therapy.
Journal ArticleDOI
Disrupted default mode network connectivity in migraine without aura
Alessandro Tessitore,Antonio Russo,Alfonso Giordano,Francesca Conte,Daniele Corbo,Manuela De Stefano,Sossio Cirillo,Mario Cirillo,Fabrizio Esposito,Fabrizio Esposito,Gioacchino Tedeschi +10 more
TL;DR: This study provides further evidence of disrupted DMN connectivity in patients with MwoA and hypothesizes that a DMN dysfunction may be related to behavioural processes such as a maladaptive response to stress which seems to characterize patients with migraine.
Journal ArticleDOI
Increased interictal visual network connectivity in patients with migraine with aura
Gioacchino Tedeschi,Antonio Russo,Francesca Conte,Daniele Corbo,Giuseppina Caiazzo,Alfonso Giordano,Renata Conforti,Fabrizio Esposito,Alessandro Tessitore +8 more
TL;DR: The imaging data revealed that patients with migraine with aura exhibit an altered resting-state visual network connectivity, which supports the hypothesis of an extrastriate cortex involvement, centred in the lingual gyrus, a brain region related to mechanisms underlying the initiation and propagation of the migraine aura.
Journal ArticleDOI
Modulation of brainstem activity and connectivity by respiratory-gated auricular vagal afferent nerve stimulation in migraine patients.
Ronald G. Garcia,Richard L. Lin,Jeungchan Lee,Jieun Kim,Riccardo Barbieri,Roberta Sclocco,Ajay D. Wasan,Robert R. Edwards,Bruce R. Rosen,Nouchine Hadjikhani,Vitaly Napadow +10 more
TL;DR: Regulation of activity and connectivity of brainstem and cortical regions involved in serotonergic and noradrenergic regulation and pain modulation may constitute an underlying mechanism supporting beneficial clinical outcomes for eRAVANS applied for episodic migraine.
References
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Journal ArticleDOI
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