Alternation of left ventricular load by a continuous-flow left ventricular assist device with a native heart load control system in a chronic heart failure model.
Mamoru Arakawa,Takashi Nishimura,Yoshiaki Takewa,Akihide Umeki,Masahiko Ando,Hideo Adachi,Eisuke Tatsumi +6 more
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TLDR
The system offers the possibility to control the left ventricular load by changing the rotational speed of a continuous-flow assist device in synchronization with the cardiac cycle and should provide the most favorableleft ventricular loading conditions for recovery of the native heart.About:
This article is published in The Journal of Thoracic and Cardiovascular Surgery.The article was published on 2014-08-01 and is currently open access. It has received 15 citations till now. The article focuses on the topics: Heart failure & Ventricular assist device.read more
Citations
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Journal ArticleDOI
Sensorless Viscosity Measurement in a Magnetically‐Levitated Rotary Blood Pump
TL;DR: A sensorless method for measuring viscosity in magnetically levitated rotary blood pumps, which requires no additional sensors or mechanisms is developed and has the possibility of being utilized for estimating flow rate.
Journal ArticleDOI
Rotational speed modulation used with continuous-flow left ventricular assist device provides good pulsatility.
Noritsugu Naito,Takashi Nishimura,Kei Iizuka,Yoshiaki Takewa,Akihide Umeki,Masahiko Ando,Minoru Ono,Eisuke Tatsumi +7 more
TL;DR: The co-pulse mode of this novel RS modulation system used with CF-LVAD (EVAHEART) may provide better pulsatility not only in the large vessels but also in the peripheral vasculature.
Journal ArticleDOI
Influence of a Rotational Speed Modulation System Used With an Implantable Continuous-Flow Left Ventricular Assist Device on von Willebrand Factor Dynamics
Noritsugu Naito,Toshihide Mizuno,Takashi Nishimura,Satoru Kishimoto,Yoshiaki Takewa,Yuka Eura,Koichi Kokame,Toshiyuki Miyata,Kazuma Date,Akihide Umeki,Masahiko Ando,Minoru Ono,Eisuke Tatsumi +12 more
TL;DR: The low NIH and the absence of significant decreases in CBCs indicate that EVAHEART is hemocompatible, regardless of whether it is operated with the RS modulation system, and suggests that it does not have marked adverse influences on vWF dynamics.
Journal ArticleDOI
Influence of a novel electrocardiogram-synchronized rotational-speed-change system of an implantable continuous-flow left ventricular assist device (EVAHEART) on hemolytic performance.
Satoru Kishimoto,Kazuma Date,Mamoru Arakawa,Yoshiaki Takewa,Takashi Nishimura,Tomonori Tsukiya,Toshihide Mizuno,Nobumasa Katagiri,Yukihide Kakuta,Daisuke Ogawa,Motonobu Nishimura,Eisuke Tatsumi +11 more
TL;DR: A novel controller for a continuous-flow left ventricular assist device (EVAHEART) that can change the pump’s rotational speed (RS) in synchronization with a patient's myocardial electrocardiogram (ECG) with the aim of facilitating cardiac recovery was developed.
Journal ArticleDOI
What Is the Optimal Setting for a Continuous-Flow Left Ventricular Assist Device in Severe Mitral Regurgitation?
Noritsugu Naito,Takashi Nishimura,Yoshiaki Takewa,Satoru Kishimoto,Kazuma Date,Akihide Umeki,Masahiko Ando,Minoru Ono,Eisuke Tatsumi +8 more
TL;DR: The counter-pulse mode of the electrocardiogram-synchronized rotational speed (RS) modulation system used with a continuous-flow LVAD may offer favorable control of MR while minimizing RV dysfunction.
References
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Journal ArticleDOI
Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device
Mark S. Slaughter,Joseph G. Rogers,Carmelo A. Milano,Stuart D. Russell,John V. Conte,David S. Feldman,Benjamin Sun,Antone Tatooles,Reynolds M. Delgado,James W. Long,Thomas C. Wozniak,Waqas Ghumman,David J. Farrar,O. Howard Frazier +13 more
TL;DR: Treatment with a continuous-flow left ventricular assist device in patients with advanced heart failure significantly improved the probability of survival free from stroke and device failure at 2 years as compared with a pulsatile device.
Journal ArticleDOI
Results of the Post-U.S. Food and Drug Administration-Approval Study With a Continuous Flow Left Ventricular Assist Device as a Bridge to Heart Transplantation: A Prospective Study Using the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support)
Randall C. Starling,Yoshifumi Naka,Andrew J. Boyle,Gonzalo V. Gonzalez-Stawinski,Ranjit John,Ulrich P. Jorde,Stuart D. Russell,John V. Conte,Keith D. Aaronson,Edwin C. McGee,William Cotts,David DeNofrio,Duc Thinh Pham,David J. Farrar,Francis D. Pagani +14 more
TL;DR: The results in a post-market approval, actual patient care setting BTT population support the original findings from the pivotal clinical trial regarding the efficacy and risk profile of the HM II LVAD.
Journal ArticleDOI
Cardiac Improvement During Mechanical Circulatory Support A Prospective Multicenter Study of the LVAD Working Group
Simon Maybaum,Donna Mancini,Steve Xydas,Randall C. Starling,Keith D. Aaronson,Francis D. Pagani,Leslie W. Miller,Kenneth B. Margulies,Susan McRee,O.H. Frazier,Guillermo Torre-Amione +10 more
TL;DR: Although cellular recovery and improvement in ventricular function are observed, the degree of clinical recovery is insufficient for device explantation in most patients with chronic heart failure.
Journal ArticleDOI
Improved Left Ventricular Function After Chronic Left Ventricular Unloading
O.H. Frazier,Claude R. Benedict,Branislav Radovancevic,Roger J. Bick,Pavel Capek,William E. Springer,Michael P. Macris,Reynolds M. Delgado,L. Maximilian Buja +8 more
TL;DR: Prospective studies are now indicated to determine whether device removal without transplantation may be beneficial in selected patients.
Journal ArticleDOI
Large Animal Models of Heart Failure A Critical Link in the Translation of Basic Science to Clinical Practice
TL;DR: Large animal models recapitulating the clinical HF phenotype in large animal models can allow for the translation of basic science discoveries into clinical therapies and translate basic science to clinical applications have successfully traveled the journey from bench to bedside.