Journal ArticleDOI
Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells
TLDR
Results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10–100 μg/ml, without any apparent toxicity.Abstract:
We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10–100 μg/ml, without any apparent toxicity.read more
Citations
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Journal ArticleDOI
Identification and characterization of ambroxol as an enzyme enhancement agent for Gaucher disease.
Gustavo Maegawa,Michael B. Tropak,Justin D. Buttner,Brigitte Rigat,Maria Fuller,Deepangi Pandit,Liangiie Tang,G. Kornhaber,Yoshitomo Hamuro,Joe T.R. Clarke,Don J. Mahuran +10 more
TL;DR: Ambroxol (ABX), a drug used to treat airway mucus hypersecretion and hyaline membrane disease in newborns, was identified and found to be a pH-dependent, mixed-type inhibitor of GCase, and modeling studies indicated that ABX interacts with both active and non-active site residues.
Journal ArticleDOI
Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy
Adrian Gillissen,D. Nowak +1 more
TL;DR: An up-to-date overview about the current knowledge of the hypothesis that oxidant-induced cellular damage underlies the pathogenesis of many human pulmonary diseases is given, and the feasibility of anti-oxidant augmentation therapy to the lung by using N-acetyl-L-cysteine or ambroxol is discussed.
Journal ArticleDOI
Tumor necrosis factor activities and cancer therapy--a perspective.
TL;DR: This review covers the structure of TNF and its receptors, various in vitro activities and in vivo activities based on studies in animal model systems and concludes with several considerations for increasing the therapeutic utility of T NF in terms of targeting, toxicity and half-life.
Journal ArticleDOI
Oxidant scavenger function of ambroxol in vitro: a comparison with N-acetylcysteine.
Adrian Gillissen,Birgit Schärling,Malgorzata Jaworska,Almut Bartling,Kurt Rasche,Gerhard Schultze-Werninghaus +5 more
TL;DR: Direct oxidant-reducing capabilities of ambroxol are demonstrated, which may be directly related to the aromatic moiety of the molecule, however, high concentrations (micromolar concentrations) are needed.
Journal ArticleDOI
Antioxidant properties of ambroxol
TL;DR: Ambroxol has antioxidant activity, which may have clinical significance in protecting lung tissue from oxidant-induced injury, and at concentrations of 1 to 5 mM, it completely protected linoleic acid from .OH-induced peroxidative damage.
References
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Journal ArticleDOI
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Journal Article
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