Journal ArticleDOI
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.
Walter Fischer,Klas Wictorin,Anders Björklund,Lawrence R. Williams,Silvio Varon,Fred H. Gage +5 more
TLDR
Continuous intracerebral infusion of NGF over a period of four weeks can partly reverse the cholinergic cell body atrophy and improve retention of a spatial memory task in behaviourally impaired aged rats.Abstract:
In aged rodents, impairments in learning and memory have been associated with an age-dependent decline in forebrain of cholinergic function, and recent evidence indicates that the cholinergic neurons in the nucleus basalis magnocellularis, the septal-diagonal band area and the striatum undergo age-dependent atrophy. Thus, as in Alzheimer-type dementia in man, degenerative changes in the forebrain cholinergic system may contribute to age-related cognitive impairments in rodents. The cause of these degenerative changes is not known. Recent studies have shown that the central cholinergic neurons in the septal-diagonal band area, nucleus basalis and striatum are sensitive to the neurotrophic protein nerve growth factor (NGF). In particular, intraventricular injections or infusions of NGF in young adult rats have been shown to prevent retrograde neuronal cell death and promote behavioural recovery after damage to the septo-hippocampal connections. It is so far not known, however, whether the atrophic cholinergic neurons in aged animals are responsive to NGF treatment. We report here that continuous intracerebral infusion of NGF over a period of four weeks can partly reverse the cholinergic cell body atrophy and improve retention of a spatial memory task in behaviourally impaired aged rats.read more
Citations
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Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial.
Michael S. Rafii,Mark H. Tuszynski,Ronald G. Thomas,David Barba,James B. Brewer,Robert A. Rissman,Robert A. Rissman,Joao Siffert,Paul S. Aisen +8 more
TL;DR: This multicenter randomized clinical trial demonstrated the feasibility of sham-surgery–controlled stereotactic gene delivery studies in patients with AD and AAV2-NGF delivery was well-tolerated but did not affect clinical outcomes or selected AD biomarkers.
Journal ArticleDOI
Dietary n-3 fatty acid deficiency decreases nerve growth factor content in rat hippocampus.
Atsushi Ikemoto,Atsumi Nitta,Shoei Furukawa,Masayo Ohishi,Akira Nakamura,Yoichi Fujii,Harumi Okuyama +6 more
TL;DR: The results indicate that dietary n-3 fatty acid deficiency and restoration affect NGF levels differently among different brain regions, particularly in the piriform cortex and hippocampus.
Journal ArticleDOI
Nerve Growth Factor: A Focus on Neuroscience and Therapy
TL;DR: The therapeutic property of NGF has been demonstrated on human cutaneous and corneal ulcers, pressure ulcer, glaucoma, maculopathy and retinitis pigmentosa.
Journal ArticleDOI
YKL-40, a Marker of Simian Immunodeficiency Virus Encephalitis, Modulates the Biological Activity of Basic Fibroblast Growth Factor
Dafna Bonneh-Barkay,Stephanie J. Bissel,Gouji Wang,Kenneth N. Fish,Georgina C. B. Nicholl,Samuel W. Darko,Rafael Medina-Flores,Michael Murphey-Corb,Premeela A. Rajakumar,Julia Nyaundi,John W. Mellors,Robert Bowser,Clayton A. Wiley +12 more
TL;DR: It is demonstrated that during lentiviral encephalitis, YKL-40 may interfere with the biological activity of bFGF and potentially of other heparin-binding growth factors and chemokines that can affect neuronal function or survival.
Journal ArticleDOI
Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease.
Maria Eriksdotter-Jönhagen,Bengt Linderoth,Göran Lind,Layth Aladellie,Ove Almkvist,Niels Andreasen,Kaj Blennow,Nenad Bogdanovic,Vesna Jelic,Ahmadul Kadir,Agneta Nordberg,Erik Sundström,Lars-Olof Wahlund,Anders Wall,Maria Kristoffersen Wiberg,Bengt Winblad,Åke Seiger,Per Almqvist,Lars Wahlberg +18 more
TL;DR: This study demonstrates that surgical implantation and removal of EC-NGF biodelivery to the basal forebrain in AD patients is safe, well tolerated and feasible.
References
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Journal ArticleDOI
Developments of a water-maze procedure for studying spatial learning in the rat
TL;DR: Developments of an open-field water-maze procedure in which rats learn to escape from opaque water onto a hidden platform are described, suggesting that they may lend themselves to a variety of behavioural investigations, including pharmacological work and studies of cerebral function.
Journal ArticleDOI
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
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Book reviewHandbook of Chemical Neuroanatomy: Methods in Chemical Neuroanatomy. Edited by A. Bjorklund and T. Hokfelt. Elsevier, Amsterdam, 1983. Cloth bound, 548 pp. UK £140. (Volume 1 in the series).
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Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
TL;DR: It is suggested that fimbrial transections resulted in retrograde degeneration of cholinergic septo-hippocampal neurons and that NGF treatment strongly attenuated this lesion-induced degeneration.
Journal ArticleDOI
Nerve growth factor treatment after brain injury prevents neuronal death
TL;DR: Cholinergic neuronal degeneration after axotomy has been proposed to be due to the loss of a retrogradely transported neurotrophic factor, possibly nerve growth factor (NGF), and NGF was continuously infused into the lateral ventricles of adult rats that had received bilateral lesions of all cholinergic axons projecting from the medial septum to the dorsal hippocampus.