E
Erik Sundström
Researcher at Karolinska Institutet
Publications - 134
Citations - 7432
Erik Sundström is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Spinal cord & Spinal cord injury. The author has an hindex of 37, co-authored 127 publications receiving 5672 citations. Previous affiliations of Erik Sundström include Karolinska University Hospital & Uppsala University.
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Journal ArticleDOI
RNA velocity of single cells
Gioele La Manno,Gioele La Manno,Ruslan A. Soldatov,Amit Zeisel,Amit Zeisel,Emelie Braun,Emelie Braun,Hannah Hochgerner,Hannah Hochgerner,Viktor Petukhov,Viktor Petukhov,Katja Lidschreiber,Maria Eleni Kastriti,Peter Lönnerberg,Peter Lönnerberg,Alessandro Furlan,Jean Fan,Lars E. Borm,Lars E. Borm,Zehua Liu,David van Bruggen,Jimin Guo,Xiaoling He,Roger A. Barker,Erik Sundström,Gonçalo Castelo-Branco,Patrick Cramer,Patrick Cramer,Igor Adameyko,Sten Linnarsson,Sten Linnarsson,Peter V. Kharchenko +31 more
TL;DR: It is shown that RNA velocity—the time derivative of the gene expression state—can be directly estimated by distinguishing between unspliced and spliced mRNAs in common single-cell RNA sequencing protocols, and expected to greatly aid the analysis of developmental lineages and cellular dynamics, particularly in humans.
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A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart
Michaela Asp,Stefania Giacomello,Ludvig Larsson,Chenglin Wu,Daniel Fürth,Xiaoyan Qian,Eva Wärdell,Joaquin Custodio,Johan Reimegård,Fredrik Salmén,Cecilia Österholm,Patrik L. Ståhl,Erik Sundström,Elisabet Åkesson,Olaf Bergmann,Magda Bienko,Agneta Månsson-Broberg,Mats Nilsson,Christer Sylvén,Joakim Lundeberg +19 more
TL;DR: A molecular approach is presented that reveals the comprehensive transcriptional landscape of cell types populating the embryonic heart at three developmental stages and that maps cell-type-specific gene expression to specific anatomical domains.
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Analysis of early human neural crest development.
TL;DR: The expression of a battery of molecular markers before, during, or following NCC migration in human embryos from Carnegie Stages 12 to 18 shows the need for the identification of additional markers to improve the capacity to investigate human NCC development, and to enable the generation of better diagnostic and therapeutic tools.
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Chronic neurochemical and behavioral changes in MPTP-lesioned C57BL/6 mice: a model for Parkinson's disease
TL;DR: It was found that MPTP induced a severe depletion of striatal DA levels that persists for 4 weeks after treatment, with less severe effects in nucleus accumbens and the olfactory tubercle, and it is suggested thatMPTP-treated C57BL/6 mice may serve as a suitable model for Parkinson's disease.
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Selective lesion of central dopamine or noradrenaline neuron systems in the neonatal rat: motor behavior and monoamine alterations at adult stage
TL;DR: The data suggest that changes in motor behavior in the adult rats, following neonatal 6-OHDA treatment, are specifically related to a DA-denervation, whereas an NA lesion does not seem to influence the spontaneous motor behavior.