Journal ArticleDOI
Amino acid neurotransmitters and their pathways in the mammalian central nervous system
G.E. Fagg,A.C. Foster +1 more
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This article is published in Neuroscience.The article was published on 1983-08-01. It has received 648 citations till now. The article focuses on the topics: Glutamic acid & Amino acid.read more
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Localization of neuronal and glial glutamate transporters
Jeffrey D. Rothstein,Lee J. Martin,Allan I. Levey,Margaret Dykes-Hoberg,Lin Jin,David Wu,Norman Nash,Ralph W. Kuncl +7 more
TL;DR: The cellular and subcellular distributions of the glutamate transporter subtypes EAAC1, GLT-1, and GLAST in the rat CNS were demonstrated using anti-peptide antibodies that recognize the C-terminal domains of each transporter.
Journal ArticleDOI
Physiological and pathophysiological roles of excitatory amino acids during central nervous system development
TL;DR: Potential therapeutic approaches may be rationally devised based on recent information about the developmental regulation of EAA receptors and their involvement in the pathogenesis of these disorders.
Journal ArticleDOI
Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain
TL;DR: The distribution of NMDA-sensitive L-[3H]glutamate-binding sites suggests that the NMDA receptor represents a major, distinct subset of excitatory amino acid receptors and indicates regions in which neurotransmission may be mediated or modulated by this receptor.
Journal ArticleDOI
Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique.
TL;DR: Antisera were raised against γ‐aminobutyric acid (GABA) or glutamate (Glu) conjugated to bovine serum albumin with glutaraldehyde to demonstrate the distributions of Glu‐like and GABA‐like immunoreactivities in parts of the perfusion‐fixed mouse and rat brain.
Journal ArticleDOI
Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors
Alan C. Foster,Graham E. Fagg +1 more
TL;DR: An evaluation of investigations designed to elucidate regulatory mechanisms at acidic amino acid binding sites is made; hypotheses such as the Ca2+-activated protease hypothesis of long-term potentiation are assessed in terms of the new binding site/receptor classification scheme.
References
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Journal Article
Evidence for the existence of monoamine-containing neurons in the central nervous system. i. demonstration of monoamines in the cell bodies of brain stem neurons.
Dahlstroem A,Fuxe K +1 more
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Dynamic response of chest wall and lung injuries in rabbits exposed to air shock waves of short duration.
Carl-Johan Clemedson,Joensson A +1 more
TL;DR: The chest walls of rabbits exposed to steep-fronted air shock waves of short duration produced by 50 g spherical charges of TNT were recorded by means of a mechano-electric motion transducer to study the correlation between the deformations of the chest and the damage inflicted to the underlying organs, especially the lungs.
Journal Article
Evidence for the existence of monoamine neurons in the central nervous system. iv. distribution of monoamine nerve terminals in the central nervous system.
Journal ArticleDOI
Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea.
Joseph T. Coyle,Robert Schwarcz +1 more
TL;DR: It is reported that the injection of kainic acid into the rat striatum causes neuronal degeneration, neurochemical alterations and behavioural responses resembling Huntington's chorea, which could provide an animal model for the study of the disease.