AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
TLDR
In this paper, an updated AMPAR trafficking and LTP model was proposed, which incorporates both extracellular as well as intracellular mechanisms, based on recent research reviewed in this special issue on AMPA receptors.About:
This article is published in Neuropharmacology.The article was published on 2021-07-13 and is currently open access. It has received 28 citations till now. The article focuses on the topics: AMPA receptor & Synaptic plasticity.read more
Citations
More filters
Posted ContentDOI
Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors
Austin R. Graves,Austin R. Graves,Richard H. Roth,Han L. Tan,Qianwen Zhu,Alexei M. Bygrave,Elena Lopez-Ortega,Alina C Spiegel,Alina C Spiegel,Ingie Hong,Richard T. Johnson,Joshua T. Vogelstein,Joshua T. Vogelstein,Daniel J. Tward,Daniel J. Tward,Michael I. Miller,Michael I. Miller,Richard L. Huganir,Richard L. Huganir +18 more
TL;DR: A suite of innovative methodologies are developed: a transgenic mouse line with fluorescently tagged endogenous AMPA receptors, two-photon imaging of hundreds of thousands of labeled synapses in behaving mice, and machine-learning-based automatic synapse detection that can longitudinally track how the strength of individual synapses changes during behavior.
Journal ArticleDOI
Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors
Austin R. Graves,Richard H. Roth,Han L. Tan,Qianwen Zhu,Alexei M. Bygrave,Elena Lopez-Ortega,Ingie Hong,Alina C Spiegel,Richard C. Johnson,Joshua T. Vogelstein,Daniel J. Tward,Michael I. Miller,Richard L. Huganir +12 more
TL;DR: In this paper, a suite of innovative methodologies are developed to track how the strength of populations of synapses changes during behavior, using two-photon imaging of hundreds of thousands of labeled synapses in behaving mice, and computer vision-based automatic synapse detection.
Journal ArticleDOI
Cholecystokinin octapeptide improves hippocampal glutamatergic synaptogenesis and postoperative cognition by inhibiting induction of A1 reactive astrocytes in aged mice.
Lei Chen,Ning Yang,Yue Li,Yitong Li,Jingshu Hong,Qian Wang,Kaixi Liu,Dengyang Han,Yongzheng Han,Xinning Mi,Chengmei Shi,Ying Zhou,Zhengqian Li,Tao-Tao Liu,Xiangyang Guo +14 more
TL;DR: The effects and mechanism of action of CCK‐8 on dNCR are explored and an immunomodulatory peptide regulates memory and learning is explored.
Journal ArticleDOI
The evolution of synaptic and cognitive capacity: Insights from the nervous system transcriptome of Aplysia
Joshua Orvis,Caroline B. Albertin,Pragya Shrestha,Shuangshuang Chen,Melanie Zheng,Cheyenne J Rodriguez,Luke J. Tallon,Anup Mahurkar,Aleksey V. Zimin,Michelle Kim,Kelvin Liu,Eric R. Kandel,Claire M. Fraser,Wayne S. Sossin,Thomas W. Abrams +14 more
TL;DR: An optimized assembly pipeline to generate an improved Aplysia nervous system transcriptome was developed, providing insights into the evolution of the synaptic proteome.
References
More filters
Journal ArticleDOI
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
Journal ArticleDOI
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis,Lonnie P. Wollmuth,Chris J. McBain,Frank S. Menniti,Katie M. Vance,Kevin K. Ogden,Kasper B. Hansen,Hongjie Yuan,Scott J. Myers,Raymond Dingledine +9 more
TL;DR: This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.
Journal ArticleDOI
Synaptic plasticity and memory: an evaluation of the hypothesis
TL;DR: It is concluded that a wealth of data support the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency.
Journal ArticleDOI
Structural basis of long-term potentiation in single dendritic spines
TL;DR: The results indicate that spines individually follow Hebb's postulate for learning and suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long- term memory.