Journal ArticleDOI
Amygdala-kindled and pentylenetetrazole-induced seizures in glutamate transporter GLAST-deficient mice.
TLDR
Results indicate that GLAST is one of factors determining seizure susceptibility and more severe stages of PTZ-induced seizures than GLAST(+/+) mice, and the latency to the onset of seizures was significantly shorter for the mutant mice.About:
This article is published in Brain Research.The article was published on 1999-10-16. It has received 110 citations till now. The article focuses on the topics: Epileptogenesis & Epilepsy.read more
Citations
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Journal ArticleDOI
Kindling and status epilepticus models of epilepsy: rewiring the brain.
TL;DR: This review focuses on the remodeling of brain circuitry associated with epilepsy, particularly in excitatory glutamate and inhibitory GABA systems, including alterations in synaptic efficacy, growth of new connections, and loss of existing connections.
Journal ArticleDOI
Mechanisms of Disease: astrocytes in neurodegenerative disease.
TL;DR: Understanding of the normative biology of astrocytes has been aided by the development of animal models in which astroCyte-specific proteins and pathways have been manipulated, and mouse models of neurodegenerative diseases have revealedAstrocyte- specific pathologies that contribute to Neurodegeneration.
Journal ArticleDOI
Glutamate as a neurotransmitter in the healthy brain.
Yun Zhou,Niels C. Danbolt +1 more
TL;DR: The present review provides a brief historical description, gives a short overview of glutamate as a transmitter in the healthy brain, and comments on the so-called glutamate–glutamine cycle.
Journal ArticleDOI
The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects
TL;DR: Selective inhibition of the neuronal glutamate transporter EAAC1 (SLC1A1) may be of therapeutic interest to block glutamate release from neurons during ischemia, and upregulation of the glial glutamate transporter GLT1 may help protect motor neurons in patients with amyotrophic lateral sclerosis (ALS), since loss of function ofGLT1 has been associated with the pathogenesis of certain forms of ALS.
Journal ArticleDOI
Glutamate transporters: animal models to neurologic disease.
TL;DR: Animal models of glutamate transporter dysfunction have revealed a significant role for these proteins in pathologic conditions such as neurodegenerative diseases, epilepsy, stroke, and central nervous system tumors.
References
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Journal ArticleDOI
Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate
Jeffrey D. Rothstein,Margaret Dykes-Hoberg,Carlos A. Pardo,Lynn A. Bristol,Lin Jin,Ralph W. Kuncl,Yoshikatsu Kanai,Matthias A. Hediger,Yanfeng Wang,Jerry P Schielke,Devin Franklin Welty +10 more
TL;DR: It is suggested that glial glutamate transporters provide the majority of functional glutamate transport and are essential for maintaining low extracellular glutamate and for preventing chronic glutamate neurotoxicity.
Journal ArticleDOI
Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1
Kohichi Tanaka,Kei Watase,Toshiya Manabe,Keiko Yamada,Masahiko Watanabe,Katsunobu Takahashi,Hisayuki Iwama,Toru Nishikawa,Nobutsune Ichihara,Tateki Kikuchi,Shigeru Okuyama,Naoya Kawashima,Seiji Hori,Misato Takimoto,Keiji Wada +14 more
TL;DR: Homozygous mice deficient in GLT-1, a widely distributed astrocytic glutamate transporter, show lethal spontaneous seizures and increased susceptibility to acute cortical injury, which can be attributed to elevated levels of residual glutamate in the brains of these mice.
Journal ArticleDOI
Localization of neuronal and glial glutamate transporters
Jeffrey D. Rothstein,Lee J. Martin,Allan I. Levey,Margaret Dykes-Hoberg,Lin Jin,David Wu,Norman Nash,Ralph W. Kuncl +7 more
TL;DR: The cellular and subcellular distributions of the glutamate transporter subtypes EAAC1, GLT-1, and GLAST in the rat CNS were demonstrated using anti-peptide antibodies that recognize the C-terminal domains of each transporter.
Journal ArticleDOI
Primary structure and functional characterization of a high-affinity glutamate transporter
TL;DR: A complementary DNA encoding an electrogenic Na+ but not Cl−-dependent high-affinity glutamate transporter (named EAAC1) is isolated from rabbit small intestine by expression in Xenopus oocytes and transcripts are found in specific neuronal structures in the central nervous system as well as in the small intestine, kidney, liver and heart.
Journal ArticleDOI
Cloning and expression of a rat brain L-glutamate transporter.
Gilia Pines,Niels C. Danbolt,Magnar Bjørås,Magnar Bjørås,Yumin Zhang,Annie Bendahan,Lars Eide,Lars Eide,Hermann Koepsell,Jon Storm-Mathisen,Erling Seeberg,Erling Seeberg,Baruch I. Kanner +12 more
TL;DR: An antibody against a glial L-glutamate transporter from rat brain is used to isolate a complemen-tary DNA clone encoding this transporter, which predicts a protein of 573 amino acids with 8–9 putative transmembrane α-helices that seems to be a member of a new family of transport molecules.