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Journal ArticleDOI

An assessment of the toxicity of polypropylene microplastics in human derived cells.

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TLDR
It was found that PP particles showed low cytotoxicity effect in size and concentration manner, however, a high concentration, small sized, DMSO method of PP particles stimulated the immune system and enhanced potential hypersensitivity to PP particles via an increase in the levels of cytokines and histamines in PBMCs, Raw 264.7 and HMC-1 cells.
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This article is published in Science of The Total Environment.The article was published on 2019-09-20. It has received 314 citations till now. The article focuses on the topics: Microplastics & Environmental pollution.

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Citations
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Environmental exposure to microplastics: An overview on possible human health effects

TL;DR: The evidence for potential negative effects of microplastics in the human body is reviewed, focusing on pathways of exposure and toxicity, with a focus on particle toxicity.
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A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health.

TL;DR: A capillary review of the literature on micro and nanoplastic exposure pathways and their potential risk to human health to summarize current knowledge with the intention of better focus future research in this area and fill knowledge gaps.
Journal ArticleDOI

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

TL;DR: The prevailing data suggest that micro- and nanoplastic accumulation in mammalian and human tissues would likely have negative, yet unclear long-term consequences, and there is a need for cellular and systemic toxicity due to micro-and nanoplastics to be better illuminated, and the underlying mechanisms defined by further work.
Journal ArticleDOI

Potential human health risks due to environmental exposure to nano- and microplastics and knowledge gaps: A scoping review.

TL;DR: It is shown that human exposure to microplastics can occur through ingestion, inhalation, and dermal contact due to their presence in food, water, air, and consumer products, and further research is needed to quantify the effects of microplastic on human health and their pathogenesis.
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Estimation of the mass of microplastics ingested - A pivotal first step towards human health risk assessment.

TL;DR: This was the first attempt to transform microplastic counts into a mass value relevant to human toxicology, and estimated that globally on average, humans may ingest 0.1-5 g of microplastics weekly through various exposure pathways.
References
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NIH Image to ImageJ: 25 years of image analysis

TL;DR: The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.
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Inflammation and cancer

TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Interleukin-10 and the interleukin-10 receptor.

TL;DR: Findings that have advanced the understanding of IL-10 and its receptor are highlighted, as well as its in vivo function in health and disease.
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Microplastics in the marine environment

TL;DR: The mechanisms of generation and potential impacts of microplastics in the ocean environment are discussed, and the increasing levels of plastic pollution of the oceans are understood, it is important to better understand the impact of microPlastic in the Ocean food web.
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Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

TL;DR: The results indicate that IL-10 has important regulatory effects on immunological and inflammatory responses because of its capacity to downregulate class II MHC expression and to inhibit the production of proinflammatory cytokines by monocytes.
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