Journal ArticleDOI
An in vivo study of the action of antiglucocorticoids on thymus weight ratio, antibody titre and the adrenal-pituitary-hypothalamus axis.
M.R. Duncan,G.R. Duncan +1 more
TLDR
One previously untested compound, 17α-methylprogesterone demonstrated in vivo an ability to significantly elevate antibody titres and increase thymus weight while simultaneously having no effect on ACTH and corticosterone blood levels.About:
This article is published in Journal of Steroid Biochemistry.The article was published on 1979-03-01. It has received 56 citations till now. The article focuses on the topics: Corticosterone & Antiglucocorticoid.read more
Citations
More filters
Journal ArticleDOI
Sex differences in HPA axis responses to stress: a review
Journal ArticleDOI
RU 38486 : potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation
TL;DR: Observations suggest that while glucocorticoid agonists form with the non-activated receptor a complex able to be activated into a more stable form (lower k-1), RU 38486 interacts strongly with theNon- activated receptor but the complex is "transformed" by heat to a less stable form, unable to translocate properly into the nucleus in order to trigger a glucoc Corticoid response.
Journal ArticleDOI
RU 38486: a potent antiglucocorticoid in vitro and in vivo.
TL;DR: The antiglucocorticoid activity of RU 38486, was studied both in vitro and in vivo, and is the first pure antagonist of dexamethasone-induced hepatic TAT.
Journal ArticleDOI
Adrenal steroids and extinction behavior: antagonism by progesterone, deoxycorticosterone and dexamethasone of a specific effect of corticosterone.
B. Bohus,E.R. de Kloet +1 more
TL;DR: Extinction behavior was nearly absent in rats adrenalectomized one hour prior to forced extinction of a passive avoidance response, indicating the agonist or antagonist interaction of naturally occurring adrenal steroids with brain cells may serve behavioral adaptation.
Journal ArticleDOI
Puberty, ovarian steroids, and stress.
TL;DR: Puberty is accompanied by a number of changes, among them increased risk for development of major depression, and the onset of these reproductive hormonal changes modulating stress systems at puberty may sensitize girls to stressful life events, which become more frequent at the transition to puberty and young adulthood.
References
More filters
Journal ArticleDOI
A quantitative immunochemical measure of the primary interaction between I BSA and antibody.
TL;DR: Most qualitative and quantitative antibody tests measure secondary effects of primary antigen-antibody interactions, but they do not always reflect the total antibody content of the antiserum with respect to the test antigen.
Journal ArticleDOI
Glucocorticoid receptors: relations between steroid binding and biological effects.
TL;DR: In this article, an allosteric model was proposed to explain the differential effects of inducer, suboptimal inducer and anti-inducer steroids on the conformational changes in the receptor molecules.
Journal ArticleDOI
Relation of steroid structure to enzyme induction in hepatoma tissue culture cells.
TL;DR: Differences in steroid behaviour do not appear to result from differences in steroid uptake or metabolism, or from an effect on general cell protein synthesis or degradation of enzyme, as well as the interaction of these steroids with an allosteric receptor system concerned with the regulation of synthesis of enzyme.
Journal Article
Mechanisms of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and b lymphocytes to the bone marrow.
TL;DR: Distribution of circulating lymphocytes to the bone marrow during corticosteroid treatment is demonstrated, resulting in an increase in immunocompetence of this compartment, while the peripheral blood lymphocyte compartment is quantitatively immunosuppressed due to a lymphocytopenia.
Journal ArticleDOI
Specific and Nonspecific Physicochemical Interactions of Glucocorticoids and Related Steroids with Rat Thymus Cells in Vitro
Allan Munck,Truls Brinck-Johnsen +1 more
TL;DR: Binding of glucocorticoids and related steroids to rat thymus cells in vitro has been measured by equilibrium and kinetic methods, adding to the evidence that the hormonally active form of cortisol is cortisol itself.