An MR fingerprinting approach for quantitative inhomogeneous magnetization transfer imaging.
Daniel J. West,Gastao Cruz,Rui Pedro A. G. Teixeira,Torben Schneider,Jacques-Donald Tournier,Joseph V. Hajnal,Claudia Prieto,Shaihan J. Malik +7 more
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TLDR
In this paper, a cyclic steady-state approach was proposed to characterize magnetization transfer (MT) and inhomogeneous MT contrasts from a single acquisition, producing both semiquantitative contrast ratios and quantitative parameter maps.Abstract:
PURPOSE Magnetization transfer (MT) and inhomogeneous MT (ihMT) contrasts are used in MRI to provide information about macromolecular tissue content. In particular, MT is sensitive to macromolecules, and ihMT appears to be specific to myelinated tissue. This study proposes a technique to characterize MT and ihMT properties from a single acquisition, producing both semiquantitative contrast ratios and quantitative parameter maps. THEORY AND METHODS Building on previous work that uses multiband RF pulses to efficiently generate ihMT contrast, we propose a cyclic steady-state approach that cycles between multiband and single-band pulses to boost the achieved contrast. Resultant time-variable signals are reminiscent of an MR fingerprinting acquisition, except that the signal fluctuations are entirely mediated by MT effects. A dictionary-based low-rank inversion method is used to reconstruct the resulting images and to produce both semiquantitative MT ratio and ihMT ratio maps, as well as quantitative parameter estimates corresponding to an ihMT tissue model. RESULTS Phantom and in vivo brain data acquired at 1.5 Tesla demonstrate the expected contrast trends, with ihMT ratio maps showing contrast more specific to white matter, as has been reported by others. Quantitative estimation of semisolid fraction and dipolar T1 was also possible and yielded measurements consistent with literature values in the brain. CONCLUSION By cycling between multiband and single-band pulses, an entirely MT-mediated fingerprinting method was demonstrated. This proof-of-concept approach can be used to generate semiquantitative maps and quantitatively estimate some macromolecular-specific tissue parameters.read more
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Journal ArticleDOI
Inhomogeneous magnetization transfer imaging: Concepts and directions for further development
David C. Alsop,Ece Ercan,Olivier M. Girard,Alex L. MacKay,Carl A. Michal,Gopal Varma,Elena Vinogradov,Guillaume Duhamel +7 more
TL;DR: Inhomogeneous magnetization transfer (ihMT) imaging as discussed by the authors is a refinement of MT imaging that isolates the MT signal dependence on dipolar order relaxation times within motion-constrained molecules.
Journal ArticleDOI
Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status
Chris W.J. van der Weijden,Emma Biondetti,Ingomar W. Gutmann,Hildebrand Dijkstra,Rory D McKerchar,Daniele de Paula Faria,Erik F. J. de Vries,J. F. Meilof,Rudi Dierckx,Valentin Prévost,A. Rauscher +10 more
TL;DR: In this paper , a review of the various myelin imaging techniques, their biophysical principles, image acquisition, data analysis and their validation status is presented, along with an overview of the current state of the art.
Journal ArticleDOI
Primary Multiparametric Quantitative Brain MRI: State-of-the-Art Relaxometric and Proton Density Mapping Techniques.
Hernan Jara,Osamu Sakai,Ezequiel Farrher,Ana-Maria Oros-Peusquens,N. Jon Shah,David C. Alsop,Kathryn E. Keenan +6 more
TL;DR: A review on brain multiparametric quantitative MRI (MP-qMRI) focuses on the primary subset of quantitative MRI parameters that represent the mobile ("free") and bound ("motion restricted") proton pools as discussed by the authors .
Journal ArticleDOI
Relaxation measurements of an MRI system phantom at low magnetic field strengths.
Michele N. Martin,Kalina V. Jordanova,Anthony B. Kos,Stephen E. Russek,Kathryn E. Keenan,Karl F. Stupic +5 more
TL;DR: In this article , temperature controlled T 1 and T 2 relaxation times were measured on NiCl 2 and MnCl 2 solutions from the ISMRM/NIST system phantom at low magnetic field strengths of 6.5 mT, 64 mT and 550 mT.
Journal ArticleDOI
Systematic review of reconstruction techniques for accelerated quantitative MRI
Banafshe Shafieizargar,Riwaj Byanju,Jan Sijbers,Stefan Klein,Arnold J. den Dekker,Dirk H. J. Poot +5 more
TL;DR: In this paper , the authors systematically review the techniques that address undersampling artifacts in accelerated quantitative magnetic resonance imaging (qMRI) in order to address under-sampling artifacts.
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SVD Compression for Magnetic Resonance Fingerprinting in the Time Domain
Debra McGivney,Eric Y. Pierre,Dan Ma,Yun Jiang,Haris Saybasili,Vikas Gulani,Mark A. Griswold +6 more
TL;DR: By compressing the size of the dictionary in the time domain, this work is able to speed up the pattern recognition algorithm, by a factor of between 3.4-4.8, without sacrificing the high signal-to-noise ratio of the original scheme presented previously.
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Modeling Magnetization Transfer for Biological-like Systems Using a Semi-solid Pool with a Super-Lorentzian Lineshape and Dipolar Reservoir
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