An update on the I blood group system.
Laura Cooling
- Vol. 35, Iss: 3, pp 85-90
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TLDR
This update of the I blood group system continues to show the Ii antigens to be increasingly recognized as important posttranslational modifiers regulating cell adhesion, signaling, differentiation, and cancer.Abstract:
CONCLUSIONS This update of the I blood group system (Cooling L. Polylactosamines, there's more than meets the "Ii": a review of the I system. Immunohematology 2010;26:133-55) continues to show the Ii antigens to be increasingly recognized as important posttranslational modifiers regulating cell adhesion, signaling, differentiation, and cancer. Ii antigens can modulate the immune response through the galectin lattice, as well as influence specific protein-protein interactions. Changes in GCNT2 and I expression accompany stem cell differentiation and are associated with tumor progression in melanoma and breast and colon cancer. Regulation of GCNT2 expression varies between cell types and differentiation. In red blood cell differentiation, GCNT2 is regulated by methylation, microRNAs, and mitogen-activated protein kinase signaling pathways. Methylation and microRNAs also play a prominent role in altering GCNT2 expression in several epithelial cancers. In congenital cataracts, GCNT2 mutations may account for 4-6 percent of all cases. GCNT2 may be particularly susceptible to gene deletion and rearrangements due to the density of Alu-repeat elements.read more
Citations
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MicroRNA-633 enhances melanoma cell proliferation and migration by suppressing KAI1.
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Characterization and statistical modeling of glycosylation changes in sickle cell disease
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TL;DR: In this paper, the results obtained through lectin arrays, glycan arrays, and mass spectrometry were used to interrogate red blood cell glycoproteins and glycan-binding proteins found in the plasma of healthy individuals and patients with sickle cell disease and sickle-cell trait.
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Bilateral congenital membranous cataracts due to Glucosaminyl (N-Acetyl) Transferase 2 (GCNT2) mutation: Life-saving genetic analysis
TL;DR: A two-week-old female child was brought to the hospital by her parents with chief complaints of white reflex in both eyes noticed at birth, which raised suspicion of intrauterine infection, which was then ruled out through appropriate investigations as discussed by the authors .
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Advances in adoptive T-cell therapy for metastatic melanoma.
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References
More filters
Journal ArticleDOI
A brief review on the mechanisms of miRNA regulation.
TL;DR: This mini-review summarized the current understanding of interactions between miRNAs and their targets, including recent advancements in deciphering the regulatory mechanisms that control the biogenesis and functionality of mi RNAs in various cellular processes.
Journal ArticleDOI
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Hong Ji,Lauren I.R. Ehrlich,Jun Seita,Peter Murakami,Akiko Doi,Paul Lindau,Hwajin Lee,Martin J. Aryee,Rafael A. Irizarry,Kitai Kim,Derrick J. Rossi,Derrick J. Rossi,Matthew A. Inlay,Thomas Serwold,Thomas Serwold,Holger Karsunky,Lena Ho,George Q. Daley,Irving L. Weissman,Andrew P. Feinberg +19 more
TL;DR: The results directly demonstrate that modulation of DNA methylation occurs during lineage-specific differentiation and defines a comprehensive map of the methylation and transcriptional changes that accompany myeloid versus lymphoid fate decisions.
Book
The Blood Group Antigen Factsbook
TL;DR: This book discusses the history and present situation of the alloantibody based and drug facts of the blood group system and protein based facts, as well as some of the controversies surrounding the publication of these facts.
Journal ArticleDOI
Principles of DNA methylation and their implications for biology and medicine.
Yuval Dor,Howard Cedar +1 more
TL;DR: Taking advantage of tissue-specific differences, methylation can be used to detect cell death and thereby monitor many common diseases with a simple cell-free circulating-DNA blood test.
Journal ArticleDOI
The galectin lattice at a glance.
TL;DR: Galectin crosslinking of plasma membrane glycans regulates diffusion, compartmentalization and endocytosis of glycoproteins and glycolipids impacting immunity, cancer and metabolism.