Anatomy and white matter connections of the fusiform gyrus
Ali H. Palejwala,Kyle P. O'Connor,Camille K Milton,Christopher D. Anderson,Panayiotis E. Pelargos,Robert G. Briggs,Andrew K. Conner,Daniel L. O'Donoghue,Chad A. Glenn,Michael E. Sughrue +9 more
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TLDR
The fusiform gyrus is an important region implicated in such tasks as the visual processing of human faces and bodies, as well as the perception of stimuli with high spatial frequencies, and post-surgical outcomes related to this region may be better understood in the context of the fiber-bundle anatomy highlighted by this study.Abstract:
The fusiform gyrus is understood to be involved in the processing of high-order visual information, particularly related to faces, bodies, and stimuli characterized by high spatial frequencies. A detailed understanding of the exact location and nature of associated white-tracts could significantly improve post-operative morbidity related to declining capacity. Through generalized q-sampling imaging (GQI) validated by gross dissection as a direct anatomical method of identifying white matter tracts, we have characterized these connections based on relationships to other well-known structures. We created the white matter tracts using GQI and confirmed the tracts using gross dissection. These dissections demonstrated connections to the occipital lobe from the fusiform gyrus along with longer association fibers that course through this gyrus. The fusiform gyrus is an important region implicated in such tasks as the visual processing of human faces and bodies, as well as the perception of stimuli with high spatial frequencies. Post-surgical outcomes related to this region may be better understood in the context of the fiber-bundle anatomy highlighted by this study.read more
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Anatomy and White Matter Connections of the Lingual Gyrus and Cuneus
Ali H. Palejwala,Nicholas B. Dadario,Isabella M. Young,Kyle P. O'Connor,Robert G. Briggs,Andrew K. Conner,Daniel L. O'Donoghue,Michael E. Sughrue +7 more
TL;DR: In this paper, a detailed cortical model elucidating the white matter connectivity associated with this area could improve our understanding of the interacting brain networks that underlie complex human processes and postoperative outcomes related to vision and language.
Journal ArticleDOI
Anatomy and White Matter Connections of the Middle Frontal Gyrus.
Robert G. Briggs,Yueh-Hsin Lin,Nicholas B. Dadario,Sihyong J. Kim,Isabella M. Young,Michael Y. Bai,Vukshitha Dhanaraj,R. Dineth Fonseka,Jorge Hormovas,Onur Tanglay,Arpan R. Chakraborty,Ty M Milligan,Carol J. Abraham,Christopher D. Anderson,Ali H. Palejwala,Andrew K. Conner,Daniel L. O'Donoghue,Michael E. Sughrue +17 more
TL;DR: In this article, a detailed understanding of the subcortical white matter tracts connected within the MFG can facilitate improved navigation of white matter lesions in and around this gyrus and explain the postoperative morbidity after surgery.
Journal ArticleDOI
Anatomy and white-matter connections of the precuneus
Onur Tanglay,Isabella M. Young,Nicholas B. Dadario,Robert G. Briggs,R. Dineth Fonseka,Vukshitha Dhanaraj,Jorge Hormovas,Yueh-Hsin Lin,Michael E. Sughrue +8 more
Abstract: Purpose Advances in neuroimaging have provided an understanding of the precuneus’(PCu) involvement in functions such as visuospatial processing and cognition. While the PCu has been previously determined to be apart of a higher-order default mode network (DMN), recent studies suggest the presence of possible dissociations from this model in order to explain the diverse functions the PCu facilitates, such as in episodic memory. An improved structural model of the white-matter anatomy of the PCu can demonstrate its unique cerebral connections with adjacent regions which can provide additional clarity on its role in integrating information across higher-order cerebral networks like the DMN. Furthermore, this information can provide clinically actionable anatomic information that can support clinical decision making to improve neurologic outcomes such as during cerebral surgery. Here, we sought to derive the relationship between the precuneus and underlying major white-mater bundles by characterizing its macroscopic connectivity. Methods Structural tractography was performed on twenty healthy adult controls from the Human Connectome Project (HCP) utilizing previously demonstrated methodology. All precuneus connections were mapped in both cerebral hemispheres and inter-hemispheric differences in resultant tract volumes were compared with an unpaired, corrected Mann–Whitney U test and a laterality index (LI) was completed. Ten postmortem dissections were then performed to serve as ground truth by using a modified Klingler technique with careful preservation of relevant white matter bundles. Results The precuneus is a heterogenous cortical region with five major types of connections that were present bilaterally. (1) Short association fibers connect the gyri of the precuneus and connect the precuneus to the superior parietal lobule and the occipital cortex. (2) Four distinct parts of the cingulum bundle connect the precuneus to the frontal lobe and the temporal lobe. (3) The middle longitudinal fasciculus from the precuneus connects to the superior temporal gyrus and the dorsolateral temporal pole. (4) Parietopontine fibers travel as part of the corticopontine fibers to connect the precuneus to pontine regions. (5) An extensive commissural bundle connects the precuneus bilaterally. Conclusion We present a summary of the anatomic connections of the precuneus as part of an effort to understand the function of the precuneus and highlight key white-matter pathways to inform surgical decision-making. Our findings support recent models suggesting unique fiber connections integrating at the precuneus which may suggest finer subsystems of the DMN or unique networks, but further study is necessary to refine our model in greater quantitative detail.
Journal ArticleDOI
Anatomy and White Matter Connections of the Parahippocampal Gyrus
Yueh-Hsin Lin,Vukshitha Dhanaraj,Alana E. Mackenzie,Isabella M. Young,Onur Tanglay,Robert G. Briggs,Arpan R. Chakraborty,Jorge Hormovas,R. Dineth Fonseka,Sihyong J. Kim,Jacky T. Yeung,Charles Teo,Michael E. Sughrue +12 more
TL;DR: In this paper, the parahippocampal gyrus tracts were mapped in both hemispheres, and a lateralization index was calculated with resultant tract volumes based on the inferior longitudinal fasciculus and cingulum.
Journal ArticleDOI
Reduced thalamic resting-state functional connectivity and impaired cognition in acute abstinent heroin users.
Min Zhang,Min Zhang,Shuang Liu,Shuang Liu,Shicong Wang,Shicong Wang,Yan Xu,Yan Xu,Longmao Chen,Longmao Chen,Ziqiang Shao,Ziqiang Shao,Xinwen Wen,Xinwen Wen,Wenhan Yang,Jun Liu,Kai Yuan,Kai Yuan +17 more
TL;DR: In this paper, the volume and resting-state functional connectivity (RSFC) differences of the thalamus were investigated between age-, gender-, and alcohol-matched 37 heroin users and 33 healthy controls.
References
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Selectivity for the Human Body in the Fusiform Gyrus
Marius V. Peelen,Paul E. Downing +1 more
TL;DR: In this article, the authors used fMRI to reveal human brain regions that respond selectively to images of faces as opposed to other kinds of objects, such as objects and cars. But they focused on the fusiform gyrus.