Journal ArticleDOI
Anesthetic Neurotoxicity — Clinical Implications of Animal Models
TLDR
The FDA collaboration SmartTots recommends undertaking large-scale clinical studies and avoiding nonurgent surgical procedures requiring anesthesia in children younger than 3 years of age.Abstract:
Some anesthetics and sedatives have been shown to cause neurotoxic effects in laboratory animals. The FDA collaboration SmartTots recommends undertaking large-scale clinical studies and avoiding nonurgent surgical procedures requiring anesthesia in children younger than 3 years of age.read more
Citations
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Journal ArticleDOI
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
Andrew Davidson,Nicola Disma,Jurgen C. de Graaff,Davinia E. Withington,Liam Dorris,Graham Bell,Robyn Stargatt,Robyn Stargatt,David C. Bellinger,David C. Bellinger,Tibor Schuster,Sarah J Arnup,Pollyanna Hardy,Rodney W. Hunt,Rodney W. Hunt,Michael Takagi,Gaia Giribaldi,Penelope L Hartmann,Ida Salvo,Neil S. Morton,Britta S von Ungern Sternberg,Britta S von Ungern Sternberg,Bruno Guido Locatelli,Niall C. T. Wilton,Anne M. Lynn,Joss J. Thomas,David M. Polaner,Oliver Bagshaw,Peter Szmuk,Anthony Absalom,Geoff Frawley,Charles B. Berde,Gillian D Ormond,Jacki Marmor,Mary Ellen McCann +34 more
TL;DR: This trial found no evidence that just under an hour of sevoflurane anaesthesia in infancy increases the risk of adverse neurodevelopmental outcome at two years of age compared to RA.
Journal ArticleDOI
Association between a single general anesthesia exposure before age 36 months and neurocognitive outcomes in later childhood
Lena S. Sun,Guohua Li,Tonya L. K. Miller,Cynthia F. Salorio,Mary W. Byrne,David C. Bellinger,Caleb Ing,Raymond Park,Jerilynn Radcliffe,Stephen R. Hays,Charles DiMaggio,Timothy J. Cooper,Virginia Rauh,Lynne G. Maxwell,Ahrim Youn,Francis X. McGowan +15 more
TL;DR: Among healthy children with a single anesthesia exposure before age 36 months, compared with healthy siblings with no anesthesia exposure, there were no statistically significant differences in IQ scores in later childhood.
Journal ArticleDOI
European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium
Cesar Aldecoa,Gabriella Bettelli,Federico Bilotta,Robert D. Sanders,Riccardo A. Audisio,Anastasia Borozdina,Antonio Cherubini,Christina Jones,Henrik Kehlet,Alasdair M.J. MacLullich,Finn M. Radtke,Florian Riese,Arjen J.C. Slooter,Francis Veyckemans,Sylvia Kramer,Bruno Neuner,Bjoern Weiss,Claudia Spies +17 more
TL;DR: This guideline is aimed to promote knowledge and education in the preoperative, intraoperative and postoperative setting not only among anaesthesiologists but also among all other healthcare professionals involved in the care of surgical patients.
Journal ArticleDOI
Lasting impact of general anaesthesia on the brain: mechanisms and relevance.
Laszlo Vutskits,Zhongcong Xie +1 more
TL;DR: Available mechanistic data linking general-anaesthesia exposure to impaired cognitive performance in both young and mature nervous systems are reviewed, providing a critical appraisal of the translational value of animal models.
Journal ArticleDOI
Association of Anesthesia and Surgery During Childhood With Long-term Academic Performance.
Pia Glatz,Rolf H. Sandin,Nancy L. Pedersen,Anna-Karin Edstedt Bonamy,Lars Eriksson,Fredrik Granath +5 more
TL;DR: Exposure to anesthesia and surgery before age 4 years has a small association with later academic performance or cognitive performance in adolescence on a population level, and the low overall difference in academic performance after childhood exposure to surgery is reassuring.
References
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Journal ArticleDOI
Cognitive and Behavioral Outcomes After Early Exposure to Anesthesia and Surgery
Randall P. Flick,Slavica K. Katusic,Robert C. Colligan,Robert T. Wilder,Robert G. Voigt,Michael D. Olson,Juraj Sprung,Amy L. Weaver,Darrell R. Schroeder,David O. Warner +9 more
TL;DR: Repeated exposure to anesthesia and surgery before the age of 2 was a significant independent risk factor for the later development of LDs but not the need for educational interventions related to emotion/behavior.
Journal ArticleDOI
Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain
Catherine E. Creeley,Krikor Dikranian,Gregory A. Dissen,Lauren D. Martin,John W. Olney,Ansgar M. Brambrink,Ansgar M. Brambrink +6 more
TL;DR: Exposure of fetal or neonatal NHP brain to propofol caused a significant increase in apoptosis of neurones, and of OLs at a stage when OLs were just beginning to myelinate axons, which indicates OLs become vulnerable to the apoptogenic action of prop ofol when they are beginning to achieve myelination competence.
Journal ArticleDOI
Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain.
Ansgar M. Brambrink,Alex S. Evers,Michael S. Avidan,Nuri B. Farber,Derek J. Smith,Lauren Drew Martin,Gregory A. Dissen,Catherine E. Creeley,John W. Olney +8 more
TL;DR: The developing rhesus macaque brain is sensitive to the apoptogenic action of ketamine at both a fetal and neonatal age, and exposure duration of 5 h is sufficient to induce a significant neuroapoptosis response at either age.
Journal ArticleDOI
Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar
Vesna Jevtovic-Todorovic,Anthony Absalom,Klas Blomgren,Ansgar M. Brambrink,G. Crosby,Deborah J. Culley,Gary Fiskum,Rona G. Giffard,Karl F. Herold,Andreas W. Loepke,Daqing Ma,Beverley A. Orser,Emmanuel Planel,W. Slikker,Sulpicio G. Soriano,G. Stratmann,Laszlo Vutskits,Zhongcong Xie,Hugh C. Hemmings +18 more
TL;DR: mounting evidence from preclinical studies reveals general anaesthetics to be powerful modulators of neuronal development and function, which could contribute to detrimental behavioural outcomes, however, definitive clinical data remain elusive.
Journal ArticleDOI
Defining Safe Use of Anesthesia in Children
TL;DR: Anesthetic agents are commonly used for a variety of medical procedures in infants and children, but data from studies in animals suggest that under certain circumstances, these drugs could adversely affect children's neurologic, cognitive, and social development.
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Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
Andrew Davidson,Nicola Disma,Jurgen C. de Graaff,Davinia E. Withington,Liam Dorris,Graham Bell,Robyn Stargatt,Robyn Stargatt,David C. Bellinger,David C. Bellinger,Tibor Schuster,Sarah J Arnup,Pollyanna Hardy,Rodney W. Hunt,Rodney W. Hunt,Michael Takagi,Gaia Giribaldi,Penelope L Hartmann,Ida Salvo,Neil S. Morton,Britta S von Ungern Sternberg,Britta S von Ungern Sternberg,Bruno Guido Locatelli,Niall C. T. Wilton,Anne M. Lynn,Joss J. Thomas,David M. Polaner,Oliver Bagshaw,Peter Szmuk,Anthony Absalom,Geoff Frawley,Charles B. Berde,Gillian D Ormond,Jacki Marmor,Mary Ellen McCann +34 more