Journal ArticleDOI
Angiotensin-converting enzyme: vascular endothelial localization
TLDR
Fluorescein-labeled antibody to rabbit pulmonary angiotensin-converting enzyme localized in the vascular endothelium of rabbit lung, liver, adrenal cortex, pancreas, kidney, and spleen demonstrated immunoreactivity.Abstract:
Fluorescein-labeled antibody to rabbit pulmonary angiotensin-converting enzyme localized in the vascular endothelium of rabbit lung, liver, adrenal cortex, pancreas, kidney, and spleen. Epithelial cells of the renal proximal tubules were the only parenchymal cells among the organs studied that demonstrated immunoreactivity.read more
Citations
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Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes
Nish Chaturvedi,A. K. Sjølie,Judith Stephenson,Heidemarie Abrahamian,Marc Keipes,Allesandro Castellarin,Zeljka Rogulja-Pepeonik,John H. Fuller +7 more
TL;DR: Lisinopril may decrease retinopathy progression in non-hypertensive patients who have type 1 diabetes with little or no nephropathy and these findings need to be confirmed before changes to clinical practice can be advocated.
Journal ArticleDOI
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
Florent Soubrier,François Alhenc-Gelas,Christine Hubert,Jacqueline Allegrini,Marie John,Geoffrey W. Tregear,Pierre Corvol +6 more
TL;DR: The sequence of ACE reveals a high degree of internal homology between two large domains, suggesting that the molecule resulted from a gene duplication, and is consistent with the presence of a single gene for ACE in the haploid human genome.
Journal ArticleDOI
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
TL;DR: Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin.
Journal ArticleDOI
Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.
TL;DR: Data indicate that Ang II regulates the expression of PAI-1 in cultured endothelial cells and that this response is mediated via a pharmacologically distinct form of the angiotensin receptor.
Journal ArticleDOI
Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes.
TL;DR: The results show that ACE is expressed in T-lymphocytes and indicate that the level of ACE expression in cells synthesizing the enzyme is genetically determined, which is highly reproducible and influenced by the polymorphism of the ACE gene.
References
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Journal ArticleDOI
The preparation and function of the hypertensin-converting enzyme.
TL;DR: It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensIn I is not, and it would appear that in intact animals the pressor activity of hypertens in I results from its rapid conversion to hypertENSin II.
Journal ArticleDOI
Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesis.
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Immunofluorescence Demonstration of a Muscle Binding, Complement-Fixing Serum Globulin Fraction in Myasthenia Gravis.
Arthur J. L. Strauss,Beatrice Carrier Seegal,Konrad C. Hsu,Peter M. Burkholder,William L. Nastuk,Kermit E. Osserman +5 more
TL;DR: A muscle binding, complement fixing component has been demonstrated in the crude globulin fraction of a pool of serum from 10 patients with myasthenia gravis of recent onset and progressive character, by means of the immunofluorescence technic.
Journal ArticleDOI
An angiotensin converting-enzyme inhibitor to identify and treat vasoconstrictor and volume factors in hypertensive patients.
Haralambos Gavras,Hans R. Brunner,John H. Laragh,Jean E. Sealey,Irene Gavras,Robert A. Vukovich +5 more
TL;DR: The antihypertensive action of nonapeptide competitive inhibitor of angiotensin-1-converting enzyme was evaluated in 13 hypertensive patients.
Journal ArticleDOI
Subcellular localization of pulmonary antiotensin-converting enzyme (kininase II).
TL;DR: Goat antibodies to pig lung angiotensin-converting enzyme (kininase II) were conjugated to microperoxidase and reaction product was revealed on the plasma membrane and caveolae of endothelial cells, especially those of capillaries and venules.
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