Anti-biofilm Activity as a Health Issue
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TLDR
The mechanisms of natural bacterial anti-biofilm strategies/mechanisms recently identified in pathogenic, commensal and probiotic bacteria and the main synthetic strategies used in clinical practice are compared and discussed, particularly for catheter-related infections.Abstract:
The formation and persistence of surface-attached microbial communities, known as biofilms, are responsible for 75% of human microbial infections (National Institutes of Health). Biofilm lifestyle confers several advantages to the pathogens, notably during the colonization process of medical devices and/or patients’ organs. In addition, sessile bacteria have a high tolerance to exogenous stress including anti-infectious agents. Biofilms are highly competitive communities and some microorganisms exhibit anti-biofilm capacities such as bacterial growth inhibition, exclusion or competition, which enable them to acquire advantages and become dominant. The deciphering and control of anti-biofilm properties represent future challenges in human infection control. The aim of this review is to compare and discuss the mechanisms of natural bacterial anti-biofilm strategies/mechanisms recently identified in pathogenic, commensal and probiotic bacteria and the main synthetic strategies used in clinical practice, particularly for catheter-related infections.read more
Citations
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References
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Journal ArticleDOI
In Vivo Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem in Pseudomonas aeruginosa Biofilm Infection
TL;DR: A biofilm lung infection model was developed to provide an objective and quantitative evaluation of the PK/PD profile of antimicrobials and the postantibiotic effect of colistin and imipenem was shorter in biofilm infections than planktonic cell infections in this model.
Journal ArticleDOI
Prevention of bloodstream infections with central venous catheters treated with anti-infective agents depends on catheter type and insertion time: evidence from a meta-analysis
TL;DR: Antibiotic and chlorhexidine–silver sulfadiazine coatings are anti-infective for short insertion times and for silver-impregnated collagen cuffs, there is evidence of lack of effect for both short- and long-term insertion.
Journal ArticleDOI
Pseudomonas aeruginosa rhamnolipids disperse Bordetella bronchiseptica biofilms
TL;DR: This report demonstrates the disruption of B. bronchiseptica biofilms by rhamnolipids secreted from Pseudomonas aeruginosa, and suggests that biosurfactants such as rhamNolipid may be utilized as antimicrobial agents for removing Bordetella bio Films.
Journal ArticleDOI
Emergence of Gentamicin-Resistant Bacteremia in Hemodialysis Patients Receiving Gentamicin Lock Catheter Prophylaxis
Daniel Landry,Gregory Braden,Stephen L. Gobeille,Sarah Haessler,Chirag K. Vaidya,Stephen J. Sweet +5 more
TL;DR: Although the use of GHL effectively lowered the CRI rate in the dialysis population, gentamicin-resistant CRIs emerged within 6 months and alternative nonantibiotic catheter locks may be preferable to decrease the incidence of CRIs without inducing resistant pathogens.
Journal ArticleDOI
Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates.
TL;DR: Two phenothiazine compounds at similar concentrations were bactericidal for starved and growing cells and appear to target a process important in both replicating and nonreplicating bacteria.