Anti-biofilm Activity as a Health Issue
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TLDR
The mechanisms of natural bacterial anti-biofilm strategies/mechanisms recently identified in pathogenic, commensal and probiotic bacteria and the main synthetic strategies used in clinical practice are compared and discussed, particularly for catheter-related infections.Abstract:
The formation and persistence of surface-attached microbial communities, known as biofilms, are responsible for 75% of human microbial infections (National Institutes of Health). Biofilm lifestyle confers several advantages to the pathogens, notably during the colonization process of medical devices and/or patients’ organs. In addition, sessile bacteria have a high tolerance to exogenous stress including anti-infectious agents. Biofilms are highly competitive communities and some microorganisms exhibit anti-biofilm capacities such as bacterial growth inhibition, exclusion or competition, which enable them to acquire advantages and become dominant. The deciphering and control of anti-biofilm properties represent future challenges in human infection control. The aim of this review is to compare and discuss the mechanisms of natural bacterial anti-biofilm strategies/mechanisms recently identified in pathogenic, commensal and probiotic bacteria and the main synthetic strategies used in clinical practice, particularly for catheter-related infections.read more
Citations
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Journal ArticleDOI
α-Chymotrypsin Immobilized on a Low-Density Polyethylene Surface Successfully Weakens Escherichia coli Biofilm Formation.
TL;DR: Plate count viability assays, as well as confocal laser scanner microscopy analysis, showed that LDPE-α-CT significantly impacts Escherichia coli biofilm formation by reducing the number of adhered cells and decreasing the matrix polysaccharide bio-volume.
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Lysinibacillus fusiformis M5 Induces Increased Complexity in Bacillus subtilis 168 Colony Biofilms via Hypoxanthine.
Ramses Gallegos Monterrosa,Stefanie Kankel,Sebastian Götze,Robert Barnett,Pierre Stallforth,Ákos T. Kovács +5 more
TL;DR: A screening method suitable for the identification of multispecies interactions and showcase L. fusiformis as a soil bacterium that is able to live alongside B. subtilis and modify the architecture of its biofilms is presented.
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Efficacy of A Poly(MeOEGMA) Brush on the Prevention of Escherichia coli Biofilm Formation and Susceptibility.
TL;DR: It is suggested that the poly(MeOEGMA) brush has potential to prevent bacterial adhesion in urinary tract devices like ureteral stents and catheters, as well as in eradicating biofilms developed in these biomedical devices.
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Potential Probiotics Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 Co-Aggregate with Clinical Isolates of Proteus mirabilis and Prevent Biofilm Formation
Ammar Algburi,Sarah A Alazzawi,Ali Ibrahim Ali Al-Ezzy,Richard Weeks,Vladimir A. Chistyakov,Michael L. Chikindas +5 more
TL;DR: This is the first report evaluating the anti-biofilm activity of probiotic spore-forming bacilli against clinical and animal UTI isolates of P. mirabilis and the mode of action for the antimicrobial substances produced by thesebacilli, subtilosin and subtilin.
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Bacteriophage-Mediated Control of Biofilm: A Promising New Dawn for the Future
TL;DR: This review aims to demonstrate the advantages and challenges of bacteriophage and its components on biofilm removal, as well as potential usage of phage cocktail, combination therapy, and genetically modified phages in a clinical setting.
References
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