Antibacterial Bisabolane-Type Sesquiterpenoids from the Sponge-Derived Fungus Aspergillus sp.
Dan Li,Ying Xu,Chang-Lun Shao,Rui-Yun Yang,Cai-Juan Zheng,Yi-Yan Chen,Xiu-Mei Fu,Pei-Yuan Qian,Zhigang She,Nicole J. de Voogd,Chang-Yun Wang +10 more
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TLDR
Four new bisabolane-type sesquiterpenoids, aspergiterpenoid A, 1, 2, 3, and 4 showed selective antibacterial activity against eight bacterial strains with the MIC values between 1.25 and 20.0 µM and the cytotoxic, antifouling, and acetylcholinesterase inhibitory activities of these compounds were examined.Abstract:
Four new bisabolane-type sesquiterpenoids, aspergiterpenoid A (1), (−)-sydonol (2), (−)-sydonic acid (3), and (−)-5-(hydroxymethyl)-2-(2′,6′,6′-trimethyltetrahydro-2H- pyran-2-yl)phenol (4) together with one known fungal metabolite (5) were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was isolated from the sponge Xestospongia testudinaria collected from the South China Sea. Four of them (1–4) are optically active compounds. Their structures and absolute configurations were elucidated by using NMR spectroscopic techniques and mass spectrometric analysis, and by comparing their optical rotations with those related known analogues. Compounds 1–5 showed selective antibacterial activity against eight bacterial strains with the MIC (minimum inhibiting concentrations) values between 1.25 and 20.0 µM. The cytotoxic, antifouling, and acetylcholinesterase inhibitory activities of these compounds were also examined.read more
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Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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Mini-review: Inhibition of biofouling by marine microorganisms.
TL;DR: Epibiotic microorganisms associated with marine algae and invertebrates have a high antifouling (AF) potential, which can be used to solve biofouling problems in industry, however, more information about the production of AF compounds by marine microorganisms in situ and their mechanisms of action needs to be obtained.
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Mini-review: marine natural products and their synthetic analogs as antifouling compounds: 2009-2014.
TL;DR: This mini-review excludes more than 200 compounds that were also reported as AF compounds but with rather weak bioactivity during the same period, and also excluded are terrestrial-derived AF compounds reported during the last five years.
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Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds
TL;DR: Thirty-five bacterial and 12 fungal genera associated with sponges that produce antimicrobials were identified, with Streptomyces, Pseudovibrio, Bacillus, Aspergillus and Penicillium as the prominent producers of antimicrobial compounds.
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Natural antifouling compound production by microbes associated with marine macroorganisms: A review
TL;DR: The microorganisms associated with sponges, corals, ascidians, seaweeds and seagrasses showed strong antimicrobial and also antifouling activities.
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Five Sesquiterpenoids from a Marine-Derived Fungus Aspergillus sp. Isolated from a Gorgonian Dichotella gemmacea
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